Antiandrogenic compositions containing indene-7-ones

Details Antiandrogenic compositions containing indene-7-ones Antiandrogenic compositions containing indene-7-ones

1983-10-19

1986-08-19

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

560256, 560100, 560107, 568373, 2604105, 260410, A61K 3112, C07C 4975, C07C 6914

Patent

active

046070540

ABSTRACT:
Novel antiandrogenic compositions comprising an antiandrogenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.-position and a non-toxic, pharmaceutical carrier or excipient and a method of treating hyperandrogenic conditions in warm-blooded animals.

REFERENCES:
patent: 3496199 (1970-02-01), Uskokovic
patent: 3499912 (1970-03-01), Uskokovic et al.
patent: 3956316 (1976-05-01), Uskokovic et al.

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