Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Reexamination Certificate
2008-03-18
2008-03-18
Swartz, Rodney P (Department: 1645)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
C424S009100, C424S130100, C424S164100, C424S168100, C424S180100, C424S200100, C424S234100, C424S248100, C435S004000, C435S007100, C435S007400, C435S015000, C435S019000, C435S183000, C435S193000, C435S440000, C435S471000
Reexamination Certificate
active
11218976
ABSTRACT:
Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting growth and/or virulence of a pathogenic mycobacterium, and methods of treating disease conditions associated with a pathogenic mycobacterium, particularly by administering an inhibitor of a mycobacterial sulfation pathway protein. The present invention further provides genetically modified mycobacteria having a defect in a sulfation pathway enzyme gene; and immunogenic compositions that include such genetically modified mycobacteria.
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Bertozzi Carolyn R.
Mougous Joseph D.
Williams Spencer J.
Borden Paula A.
Bozicevic Field & Francis LLP
Swartz Rodney P
The Regents of the University of California
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