Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form
Reexamination Certificate
2008-04-15
2008-04-15
Kishore, Gollamudi S. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
C514S832000, C514S937000
Reexamination Certificate
active
10253572
ABSTRACT:
A stable FC emulsion is described. The FC emulsion of the present invention comprises a continuous FC immiscible hydrophilic liquid phase and a dispersed phase comprising FC suspended as droplets within the continuous phase. The emulsion further comprises an emulsifying agent and a stabilizing agent. The stabilizing agent of the present invention reduces the ability of the FC droplets to move within the continuous phase. The present invention also provides a method of making a FC emulsion. The method comprises mixing an FC immiscible hydrophilic liquid and a solid emulsifying agent by agitation at a temperature elevated above the phase transition temperature of the emulsifying agent and below the boiling temperature of the FC immiscible hydrophilic liquid, and adding FC to the mixture of step (a) and agitating at the elevated temperature to disperse droplets of FC in the FC immiscible hydrophilic liquid to form the FC emulsion. The invention also provides another method of making an FC emulsion, which does not require a solid emulsifying agent. The method comprises mixing an FC immiscible hydrophilic liquid and an emulsifying agent to form a first mixture; mixing a stabilizing agent with the first mixture to form a second mixture; and mixing FC with the second mixture to form a third mixture to disperse droplets of FC in the FC immiscible hydrophilic liquid and to form the FC emulsion, wherein the stabilizing agent reduces ability of the droplets to move within a continuous phase of the FC emulsion.
REFERENCES:
patent: 3778381 (1973-12-01), Rosano et al.
patent: 3932614 (1976-01-01), Scott
patent: 3958014 (1976-05-01), Watanabe et al.
patent: 4151108 (1979-04-01), Sorensen et al.
patent: 4252827 (1981-02-01), Yokoyama et al.
patent: 4323563 (1982-04-01), Takami et al.
patent: 4366169 (1982-12-01), White
patent: 4569784 (1986-02-01), Moore
patent: 4722904 (1988-02-01), Feil
patent: 4758431 (1988-07-01), Osterholm
patent: 4865836 (1989-09-01), Long, Jr.
patent: 4879062 (1989-11-01), Moore
patent: 4927623 (1990-05-01), Long, Jr.
patent: 5149319 (1992-09-01), Unger
patent: 5160733 (1992-11-01), Berthiaume et al.
patent: 5573757 (1996-11-01), Reiss et al.
patent: 5573759 (1996-11-01), Blank
patent: 5576064 (1996-11-01), Fructus
patent: 5637318 (1997-06-01), Gross et al.
patent: 5643601 (1997-07-01), Gross et al.
patent: 5667772 (1997-09-01), Zastrow et al.
patent: 5684050 (1997-11-01), Clark, Jr. et al.
patent: 5827222 (1998-10-01), Klatz et al.
patent: 5834519 (1998-11-01), Spears
patent: 5851444 (1998-12-01), Hansell et al.
patent: 5851544 (1998-12-01), Penska et al.
patent: 5885564 (1999-03-01), Zastrow et al.
patent: 5922305 (1999-07-01), Spears
patent: 5922313 (1999-07-01), Steward et al.
patent: 5925364 (1999-07-01), Ribier et al.
patent: 5958377 (1999-09-01), Spears
patent: 6030603 (2000-02-01), Lohrmann et al.
patent: 6066328 (2000-05-01), Ribier et al.
patent: 6113919 (2000-09-01), Reiss et al.
patent: 6121314 (2000-09-01), Richter et al.
patent: 6169117 (2001-01-01), Spears
patent: 6197279 (2001-03-01), Spears
patent: 6228378 (2001-05-01), Takanabe et al.
patent: 6238645 (2001-05-01), Spears
patent: 6262126 (2001-07-01), Meinert
patent: 6479058 (2002-11-01), McCadden
patent: 2002/0102216 (2002-08-01), Lanza et al.
patent: 2002/0164379 (2002-11-01), Nishihara et al.
patent: 4221268 (1994-01-01), None
patent: 1549038 (1979-07-01), None
patent: WO 96/40057 (1996-12-01), None
Oxynoid et al. Application of fluorcarbon emulsions as components of cosmetic and medical ointments. Art. Cells, Blood Subs., and Immob. Biotech. 1994; 22(4), 1331-1336.
Dinkelmann S et al. A system establishing compatibility profiles for artificial oxygen carriers and other substances. Database Biosis ′Online! Biosciences Information Service 2001. 29(1):1073-1199.
Reiss JG et al. Fluorinated materials for in vivo oxygen transport (blood substitutes), diagnosis and drug delivery. Biomaterials 1998. 19:1529-1539.
Creech Jeffrey L.
Hsu Li-Chien
Kivinski Margaret A.
Zalesky Paul J.
Kishore Gollamudi S.
Kivinski Margaret A.
TherOx, Inc.
LandOfFree
Perfluorocarbon emulsions with non-fluorinated surfactants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Perfluorocarbon emulsions with non-fluorinated surfactants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Perfluorocarbon emulsions with non-fluorinated surfactants will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3940307