Recombinant monoclonal antibodies and corresponding antigens...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S133100, C424S138100, C435S007230, C530S388300

Reexamination Certificate

active

11404566

ABSTRACT:
The present invention provides for purified or highly pure recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens (CPAA), along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to said nucleic acids and uses for said sequences.

REFERENCES:
patent: 4810781 (1989-03-01), Hollinshead et al.
patent: 5431897 (1995-07-01), Welt et al.
patent: 5712369 (1998-01-01), Old et al.
patent: 5851526 (1998-12-01), Welt et al.
patent: 6190640 (2001-02-01), Welt et al.
patent: 6291235 (2001-09-01), Welt et al.
patent: 6307026 (2001-10-01), King et al.
patent: 6652853 (2003-11-01), Welt et al.
patent: 7125689 (2006-10-01), Carr et al.
patent: 2003/0031671 (2003-02-01), Welt et al.
patent: 2003/0040027 (2003-02-01), Ritter et al.
patent: 2007/0031327 (2007-02-01), Luzzi et al.
Burgess et al, Journal of Cell Biology vol. 111 Nov. 1990 2129-2138.
Lazar et al Molecular and Cellular Biology Mar. 1988 vol. 8 No. 3 1247-1252).
Schwartz et al, Proc Natl Acad Sci USA vol. 84:6408-6411 (1987).
Lin et al Biochemistry USA vol. 14:1559-1563 (1975).
Rudikoff et al (Proc Natl Acad Sci USA 1982 vol. 79 p. 1979).
Heath, J. K. et al., The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily,Proc. Natl. Acad. Sci. USA, 94(2):469-474, 1997.
Hollinshead, A.C. et al., Separation of skin reactive intestinal cancer antigen from the carcinoembryonic antigen of Gold,Science, 177(52):887-889, 1972.
Hollinshead, A. et al., Further comparison's of separated intestinal cancer, fetal intestinal and normal intestinal soluble membrane antigen and the role of tumor related antigens in the diagnosis and treatment of intestinal cancer, Proc.Second Intl. Symp. Cancer Detection and Prevention, Bologna, Italy, pp. 616-620, Apr. 1973.
Hollinshead, A. et al., Skin-reactive soluble antigen from intestinal cancer-cell-membranes and relationship to carcinoembryonic antigens,Lancet, 1(7658):1191-1195, 1970.
Hollinshead, A. et al., Specific active immunotherapy in patients with adenocarcinoma of the colon utilizing tumor-associated antigens (TAA). A phase I clinical trial,Cancer, 56:480-489, 1985.
Johnstone, C. N. et al., Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells,Am. J. Physiol. Gastrointest. Liver Physiol., 2000 279(3):G500-G510, 2000.
Kurihara, M. et al., Soluble membrane antigens of gastric cancer cells: an analysis and study of activity in inducing cell-mediated immune responses,J. Jap. Soc. Cancer Ther., 14(3):313-324, 1979.
Ritter, G. et al., Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium,Biochem. Biophys. Res. Commun., 236(3):682-686, 1997.
Ritter, G. et al., Serological analysis of human anti-human antibody responses in colon cancer patients treated with repeated doses of humanized monoclonal antibody A33,Cancer Res., 61:6851-6859, 2001.
Welt, S., Phase I study of anticolon cancer humanized antibody A33,Clin. Cancer Res., 9:1338-1346, 2003.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Recombinant monoclonal antibodies and corresponding antigens... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Recombinant monoclonal antibodies and corresponding antigens..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant monoclonal antibodies and corresponding antigens... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3940129

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.