Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2008-09-09
2008-09-09
Davis, Brian J (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S307000, C564S337000, C514S651000
Reexamination Certificate
active
10514829
ABSTRACT:
The invention provides novel alkoxyaminochalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic, bacteriostatic, and bacteriocidal agents.
REFERENCES:
patent: 93/17671 (1993-09-01), None
patent: 99/00114 (1999-01-01), None
Database CAPLUS on STN, Acc. No. 1992:629356, Bourguet et al., Biochemical and Biophysical Research Communications (1992), 187(2), p. 711-716 (abstract).
Bradlerova et al., “Preparation and properties of dialkylaminoethoxyazachacones,” Chem. Zvesti 37 (2) 251-262 (1983).
Bradlerova et al., “Preparation and Properties of Heterocycloalkylethoxyazachalcones” Acta Facultatis pharmaceuticae, Tom.XLIV.1990, pp. 85-102.
Abstract of Patent CS218450 to Bradlerova, Alena, Feb. 25, 1983.
Abstract of Patent CS218446 to Bradlerova et al., Feb. 25, 1983.
Doshi et al., “Synthesis and biological evaluation of some novel isoxazoles and cyanopyridnes, a new class of potential anti-tubercular agents,” Indian Journal of Chemistry, vol. 38B, Mar. 1999, pp. 348-352.
Boesen Thomas
Kromann Hasse
Larsen Mogens
Nielsen Mette Bjerg
Nielsen Simon Feldbæk
Davis Brian J
Hunton & Williams LLP
Lica Pharmaceuticals A/S
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