Migraine and vasodilation treatment

Details Migraine and vasodilation treatment Migraine and vasodilation treatment

2008-07-08

2008-07-08

Nguyen, Bao-Thuy L. (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C530S387900, C530S830000, C435S023000

Reexamination Certificate

active

10257435

ABSTRACT:
The present invention related to the use of Cystatin in predicting onset of migraines. The invention also relates to the use of Cystatin as a vasodilatory agent. The invention also relates to antagonists to Cystatin for use in treating and preventing and treating migraine attacks.

REFERENCES:
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patent: WO 01/68851 (2001-09-01), None
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Shi, et al., “Cystatin C deficiency in human atherosclerosis and aortic aneurysms”J. Clin. Invest. 104, 1191-97 (1999).
Williamson, et al. “The novel anti-migraine agent rizatriptan inhibits neurogenic dural vasodilation and extravasation”Eur. J. Pharmacol., 328, 61-64 (1997).
Williamson, et al. “Role of opioid receptors in neurogenic dural vasodilation and sensitization of trigeminal neurons in anaesthetized rats”Brit. J. Pharmacol, 133, 807-14 (2001).
Goadsby, “Neuroimaging in Headache”Microscopy Research and Technique, 53, 179-187 (2001).
Shi, et al., “Cystatin C deficiency in human atherosclerosis and aortic aneurysms”J. Clin. Invest.104, 1191-97 (1999).
Williamson, et al. “The novel anti-migraine agent rizatriptan inhibits neurogenic dural vasodilation and extravasation”Eur. J. Pharmacol, 328, 61-64 (1997).
Williamson, et al. “Role of opioid receptors in neurogenic dural vasodilation and sensitization of trigeminal neurons in anaesthetized rats”Brit. J. Pharmacol, 133, 807-14 (2001).

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