Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-03-04
2008-03-04
Carlson, Karen Cochrane (Department: 1656)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C530S350000
Reexamination Certificate
active
09876773
ABSTRACT:
Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted With interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFNα and IFNγ. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
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Appendix A—Sequence Alignment of SEQ ID No. 3 and SEQ ID No. 1, no date.
Appendix B -Sequence Alignement of SEQ ID No. 3 and SEQ ID No. 5, no date.
Appendix C—Sequence Alignement of SEQ ID No. 3 and SEQ ID No. 7, no date.
Appendix D—Sequence Alignement of SEQ ID No. 3 and SEQ ID No. 9, no date.
Appendix E—Sequence Alignement of SEQ ID No. 3 and SEQ ID No. 11, no date.
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Darnell, Jr. James E.
Fu Xin-Yuan
Schindler Christian W.
Wen Zilong
Zhong Zhong
Carlson Karen Cochrane
Klauber & Jackson
Noakes Suzanne M.
The Rockfeller University
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