Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2008-03-18
2008-03-18
Romeo, David S (Department: 1647)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069700, C435S070100, C435S320100, C435S325000, C536S023100, C536S023400, C536S023500
Reexamination Certificate
active
10817607
ABSTRACT:
The present invention provides novel polynucleotides encoding HBMYP2X7v polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HBMYP2X7v polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
REFERENCES:
patent: 6133434 (2000-10-01), Buell et al.
patent: 6509163 (2003-01-01), Buell et al.
patent: 2004/0180332 (2004-09-01), Powell
patent: 2006/0063227 (2006-03-01), Jacobs et al.
patent: 1199372 (2002-04-01), None
patent: 1473367 (2004-11-01), None
patent: WO98/17687 (1998-04-01), None
patent: WO01/19988 (2001-03-01), None
patent: WO03/020762 (2003-03-01), None
patent: WO03/025138 (2003-03-01), None
patent: WO03/083085 (2003-10-01), None
patent: WO03/087768 (2003-10-01), None
patent: WO2004/023973 (2004-03-01), None
patent: WO2004/047749 (2004-06-01), None
Abbracchio, et al., “Purinoceptors: Are There Families of P2X and P2Y Purinoceptors”, Pharmacol. Ther., vol. 64, pp. 45-475 (1994).
Adinolfi, et al., “Basal Activation of the P2X7ATP Receptor Elevates Mitochondrial Calcium and Potential, Increases Cellular ATP Levels, and Promotes Serum-independent Growth”, Molec. Biol. of the Cell, vol. 16, pp. 3260-3272 (2005).
Altschul, et al., “Gapped Blast and PSI-BLAST: a new generation of protein database search programs”, Nucleic Acids Res., vol. 25 (17), pp. 3389-3402 (1997).
Atkinson, et al., “An ATP-gated Ion Channel at the Cell Nucleus”, Nature, vol. 420, pp. 42 (2002).
Barden, et al., “Analysis of Single Nucleotide Polymorphisms in Genes in the Chromosome 12Q24.31 Region Points to P2RX7 as a Susceptibility Gene to Bipolar Affective Disorder”, Amer. J Med Genet Part B, vol. 141B, pp. 374-382 (2006).
Barden, et al., “Specific Detection of Non-Functional Human P2X7Receptors in HEK293 Cells and B-lymphocytes”, FEBS Ltrs., vol. 538, pp. 159-162 (2003).
Bianchi, et al., “Pharmacological Characterization of Recombinant Human and Rat P2X Receptor Subtypes”, Eur. J. Pharm., vol. 376, pp. 127-138 (1999).
Budagian, et al., “Signaling through P2X7 Receptor in Human T Cells Involves p56/ck, MAP Kinases, and Transcription Factors AP-1 and NF-κB”, J. Biol Chem., vol. 278(3), pp. 1549-1560 (2003).
Buell, et al., “Gene Structure and Chromosomal Localization of the Human P2X7Receptor”, Receptors Channels., vol. 5, pp. 347-354 (1998).
Burnstock G., “Purinergic Nerves”, Pharmacol. Reviews, vol. 24(3), pp. 509-581 (1972).
Cheewatrakoolpong, et al., “Identification and Characterization of Splice Variants of the Human P2X7ATP Channel”, Biochem. Biophs. Res. Comm., vol. 332, pp. 17-27 (2005).
Chessell, et al., “Disruption of the P2X7Purinoceptor Gene Abolishes Chronic Inflammatory and Neuropathic Pain”, vol. 114, pp. 386-396 (2005).
Denliger, et al., “A Novel Assay to Detect Nucleotide Receptor P2X7Genetic Polymorphisms Influencing Numerous Innate Immune Functions”, J. Endotoxin Res., vol. 10(2), pp. 137-142 (2004).
Denlinger, et al., “Mutation of a Dibasic Amino Acid Motif Within the C Terminus of the P2X7Nucleotide Receptor Results in Trafficking Defects and Impaired Function”, J. Immun., vol. 171, pp. 1304-1311 (2003).
Elliott, et. al., “The P2X7Receptor is a Candidate Product of Murine and Human Lupus Susceptibility Loci: a Hypothesis and Comparison of Murine Allelic Products”, Arthritis Res. Ther., vol. 7, pp. R468-R475 (2005).
Feng, et al., “ATP Stimulates GRK-3 Phosphorylation and β-Arrestin-2-Dependent Internalization and P2X7Receptor”, Am J. Physiol. Cell Physiol., vol. 288, pp. C1342-C1356 (2005).
Feng, et al., “A Truncated P2X7Receptor Variant (P2X7-1) Endogenously Expressed in Cervical Cancer Cells Antagonizes the Full-Length P2X7Receptor through Hetero-Oligomerization”, J. Biol. Chem., vol. 281(25), pp. 17228-17237 (2006).
Fernando, et al., “Gene Dosage Determines the Negative Effects of Polymorphic Alleles of the P2X7Receptor on Adenosine Triphosphate-Mediated Killing of Mycobacteria by Human Macrophages”, J. Infec. Diseases, vol. 192, pp. 149-155 (2005).
Cabrini, et al., “A His-155 to Tyr Polymorphism Confers Gain-of-Function to the Human P2X7Receptor of Human Leukemic Lymphocytes”, J. Immunol., vol. 175, pp. 82-89 (2005).
Fredholm, et al., “VI. Nomenclature and Classification of Purinoceptors”, Pharm. Rev., vol. 46(2), pp. 143-156 (1994).
Georgiou, et al., “Human Epidermal and Monocyte-Derived Langerhans Cells Express Functional P2X7Receptors”, J. Invest. Dermatol., vol. 125, pp. 482-490 (2005).
Gorodeski, et al., “Estrogen Attenuates P2X7-R—Mediated Apoptosis of Uterine Cervical Cells by Blocking Calcium Influx”, Nucleosides, Nucleotides & Nucleic Acids, vol. 23(8/9), pp. 1287-1293 (2004).
Greig, et al, “Expression of Purinergic Receptors In Non-melanoma Skin Cancers and Their Functional Roles in A431 Cells”, J. Invest. Dermatol., vol. 121, pp. 315-327 (2003).
Greig, et al., “Purinergic Receptors Are Part of a Functional Signaling System for Proliferation and Differentiation of Human Eipdermal Keratinocytes”, J. Invest. Dermatol., vol. 120, pp. 1007-1015 (2003).
Gu, et al., “An Arg307to Gln Polymorphism within the ATP-Binding Site Causes Loss of Function of the Human P2X7Receptor”, J. Biol. Chem., vol. 279(30), pp. 31287-31295 (2004).
Gu, et al., “Rapid ATP-Induced Release of Matrix Metalloproteinase 9 is Mediated by the P2X7Receptor”, Blood, vol. 107(12), pp. 4946-4953 (2006).
Kim, et al., “Proteomic and Functional Evidence for a P2X7Receptor Signalling Complex”, EMBO J., vol. 20(22), pp. 6347-6358 (2001).
Le, et al., “Primary Structure and Expression of a Naturally Truncated Human P2X ATP Receptor Subunit from Brain and Immune System”, FEBS Ltrs., vol. 418, pp. 195-199 (1997).
Li, et al., “Regulation of the P2X7 Receptor Permeability to Large Molecules by Extracellular C1 and Na+”, J. Biol. Chem., vol. 280(29), pp. 26922-26927 (2005).
Longhurst, et al., “The Human P2X1Receptor: Molecular Cloning, Tissue Distribution, and Localization to Chromosome 17”, Biochim. Biophys. Acta, vol. 1308, pp. 185-188 (1996).
Lynch, et al., “Molecular and Functional Characterization of Human P2X2Receptors”, Molec. Pharmacol., vol. 56, pp. 1171-1181 (1999).
Mammalian Gene Collection (MGC) Program Team, “Generation and Initial Analysis of More than 15,000 Full-Length Human and Mouse cDNA Sequences”, PNAS, vol. 99(26), pp. 16899-16903 (2002).
Narcisse, et al., “The Cytokine IL-1β Transiently Enhances P2X7Receptor Expression and Function in Human Astrocytes”, GLIA, vol. 49, pp. 245-258 (2005).
North Alan R., “Molecular Physiology of P2X Receptors”, Physiol. Rev., vol. 82, pp. 1013-1067 (2002).
Nuckel, et al., “1513A/C Polymorphism in the P2X7 Receptor Gene in Chronic Lymphocytic Leukemia: Absence of Correlation with Clinical Outcome”, Eur. J. Haematol, vol. 72, pp. 259-263 (2004).
Parvathenani, et al., “P2X7Mediates Superoxide Production in Primary Microglia and Is Up-Regulated in a Transgenic Mouse Model of Alzheimer's Disease”, J. Biol. Chem., vol. 278(15), pp. 13309-13317 (2003).
Penolazzi, et al., “N-Arylpiperazine modified analogues of the P2X7receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts”, J. Biomed. Science, vol. 12, pp. 1013-1020 (2005).
Raffaghello, et al., “The P2X7Receptor Sustains
Feder John N.
Franco Diana L.
Lewis Martin A.
Ramanathan Chandra S.
Bristol--Myers Squibb Company
D'Amico Stephen C.
Gamett Daniel C
Romeo David S
LandOfFree
Polynucleotide encoding a novel human P2X7 splice variant,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polynucleotide encoding a novel human P2X7 splice variant,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotide encoding a novel human P2X7 splice variant,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3928075