Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-02-18
1997-06-03
Lilling, Herbert J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
530395, 536 111, 536 41, 536 64, 536 186, 536124, 536126, A61K 3816, C07K 100, C07H 100, C07H 1524
Patent
active
056356129
ABSTRACT:
The invention relates to methods that permit the rapid construction of oligosaccharides and other glycoconjugates. Methods for forming multiple glycosidic linkages in solution in a single step are disclosed. The invention takes advantage of the discovery that the relative reactivity of glycoside residues containing anomeric sulfoxides and nucleophilic functional groups can be controlled. In another aspect of the invention, the reactivity of activated anomeric sugar sulfoxides is utilized in a solid phase method for the formation of glycosidic linkages. The methods disclosed may be applied to the preparation of specific oligosaccharides and other glycoconjugates, as well as to the preparation of glycosidic libraries comprising mixtures of various oligosaccharides, including glycoconjugates, which can be screened for biological activity.
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Lilling Herbert J.
The Trustees of Princeton University
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