Substituted acylhydroxamic acids and method of reducing...

Details Substituted acylhydroxamic acids and method of reducing... Substituted acylhydroxamic acids and method of reducing...

2008-03-18

2008-03-18

Coleman, Brenda L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S411000, C514S416000, C514S417000, C546S142000, C546S277100, C548S210000, C548S451000, C548S472000, C548S477000

Reexamination Certificate

active

10786822

ABSTRACT:
Imido and amido substituted acylhydroxamidic acids which reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propandylamino)propanoate.

REFERENCES:
patent: 7034052 (2006-04-01), Man et al.
Borkakoti, Matrix Metalloproteases: Variations on a Theme, Progress in Biophysics & Molecular Biology, 1998, vol. 70, No. 1, pp. 73-94.
Yu et al., Matrix Metalloproteases: Novel Targets for Directed Cancer Therapy, Drugs & Aging, Sep. 1997, vol. 11, No. 3, pp. 229-244.

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