Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-05-13
2008-05-13
Fredman, Jeffrey (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
11031450
ABSTRACT:
The invention provides novel methods and compositions for modulating gluconeogenesis through modulation of PGC-1 activity or expression. Also provided are methods for identifying compounds that modulate gluconeogenesis through modulation of PGC-1 activity or expression, as well as methods for identifying compounds that modulate the interaction of PGC-1 with PGC-1 target molecules. Further provided are methods for treating disorders characterized by aberrant gluconeogenesis.
REFERENCES:
patent: 6166192 (2000-12-01), Spiegelman et al.
patent: 2290944 (1998-12-01), None
patent: 2353086 (2000-06-01), None
patent: WO 98/54220 (1998-12-01), None
patent: WO 00/32215 (2000-06-01), None
Emilsson et al (Metabolism (2000) 49(12):1610-1615).
Ayala et al., “Conservation of an Insulin Response Unit Between Mouse and Human Glucose-6-Phosphatase Catalytic Subunit Gene Promoters,” Diabetes, 48:1885-1889 (1999).
Barthel et al., “Novel concepts in insulin regulation of hepatic gluconeogenesis,” Am. J. Physiol. Endocrinol. Metab., 285:2685-692 (2003).
Boss, O. et al., Role of the β3-adrenergic receptor and/or a putative β4,-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-γ coactivator-1.Biochem. Biophys. Res. Commun. Aug. 11, 1999; 261(3):870-6.
Crawford et al., “Nuclear Factor I Regulates Expression of the Gene for Phosphoenolpyruvate Carboxykinase (GTP),” J. Biol. Chem., 273(22):13387-13390 (1998).
DeFronzo, R.A., “Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes,” Diabetes Rev. 5(3):177-269 (1997).
Gomez-Ambrosi J. et al., “Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a β3- adrenergic agonist and lack of effect of leptin,” Mol. Coll. Endocrinol. May 15;176(1-2):85-90 (2001).
Hall, R.K. et al., “The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoeno/pyruvate carboxykinase gene transcription by glucocorticoids,” Proc. Natl. Acad. Sci. U.S.A. 92(2):412-6 (1995).
Hanson, R.W. et al., “Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expressio,”. Annu. Rev. Biochem. 66:581-611 (1997).
Herzog et al., “Characterization of the human liver fructose-1,6-bisphosphatase gene promoter,” Biochem. J., 351:385-392 (2000).
Hinz, W. et al., “Recombinant human uncoupling protein-3 increases thermogenesis in yeast cells,” FEBS Lett. 448(1):57-61 (1999).
Kakuma et al., “Role of leptin in peroxisome proliferator-activated receptor gamma coactivator 1 expression,” Endocrinology, 141(12):4576-82 (2000).
Knutti, D. et al., “A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen,” Mol. Cell. Biol. (7):2411-22 (2000).
Lehman, J.J. et al., “Peroxisome proliferator-activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis,” J. Clin. Invest. 106(7):847-56 (2000).
Lowell, B.B. et al., “Towards a molecular understanding of adaptive thermogenesis,” Nature. 404(6778):652-60 (2000).
Michael, M.D. et al., “Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction,” Mol. Cell 6(1):87-97 (2000).
Mitchell, J. et al., “Integration of multiple signals through a complex hormone response unit in the phosphoenolpyruvate carboxykinase gene promoter,” Mol. Endocrinol. 8(5):585-94 (1994).
Nordlie, R.C. et al., “Regulation of glucose production by the liver,” Annu. Rev. Nutr. 19:379 406 (1999).
Olefsky, J.M., “Treatment of insulin resistance with peroxisome proliferator-activated receptor γ agonists,” J. Clin. Invest. 106(4):467-72 (2000).
Pilkis, S.J. et al., “Molecular physiology of th regulation of hepatic gluconeogenesis and glycolysis,” Annu. Rev. Physiol. 54:885-909 (1992).
Puigserver, P. et al., “A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis,” Cell 92(6):829-39 (1998).
Puigserver, P. et al. “Activation of PPAR γ coactivator-1 through transcription factor docking,” Science 286(5443):1368-71 (1999).
Radziuk J., Hepatic glycogen in humans. II. Gluconeogenetic formation after oral and intravenous glucose, Am. J. Physiol. 257(2 Pt 1):E158-69 (1989).
Shulman, G.I. et al., “Quantitative comparison of pathways of hepatic glycogen repletion in fed and fasted humans,” Am. J. Physiol. 259(3 Pt 1):E335-41 (1990).
Spiegelman, B.M., “PPAR- γ: adipogenic regulator and thiazolidinedione receptor,” Diabetes 47(4):507-14 (1998).
Tcherepanova I. et al., “Modulation of estrogen receptor-α transcriptional activity by the coactivator PGC-1,” J. Biol. Chem. 275(21):16302-8 (2000).
Vega, R.B. et al., “The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes,” Mol. Cell. Biol. 20(5):1868-76 (2000).
Vidal-Puig, A. et al., “UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue,” Biochem. Biophys. Res. Commun. 235(1):79-82 (1997).
Vidal-Puig, A. et al., “Metabolism. Controlling the glucose factory,” Nature 413(6852):125-6 (2001).
Wiemsperger, N.F. et al., “The antihyperglycaemic effect of metformin: therapeutic and cellular mechanisms,” Drugs 58 Suppl 1:31-9 (1999).
Wu, Z. et al., “Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1,” Cell. 98(1):115-24 (1999).
Yoon, J.C. et al., “Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1,” Nature 413(6852):131-8 (2001).
Yu et al., “Impact of endotoxin on UCP homolog mRNA abundance, thermoregulation, and mitochondrial proton leak kinetics,” Am. J. Physiol. Endocrinol. Metab., 279:E433-446 (Aug. 2000).
Zhang, C.-Y. et al. ,“Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system,” FEBS Lett. 449(2-3):129-34 (1999).
Spiegelman Bruce M.
Yoon Clifford Hyunsuk
Dana-Farber Cancer Institute Inc.
Foley & Hoag LLP
Fredman Jeffrey
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