Substituted pyrrolidin-3-yl-alkyl-piperidines

Details Substituted pyrrolidin-3-yl-alkyl-piperidines Substituted pyrrolidin-3-yl-alkyl-piperidines

1994-10-31

1997-06-03

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514318, 514321, 514326, 546 20, 546186, 546193, 546194, 546196, 546208, 546212, A61K 3144, A61K 31445, C07D47110, C07D40106

Patent

active

056355106

ABSTRACT:
The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein.

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