Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-05-13
2008-05-13
Shameem, Golam M. M. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S106000, C544S111000, C544S133000, C544S135000, C514S231200, C514S231500, C514S233500
Reexamination Certificate
active
11183503
ABSTRACT:
The present invention relates to compounds of formulae IA and IBwhereinR1and R2are each independently lower alkyl or —(CH2)m—O-lower alkyl, or together with the N atom to which they are attached form a heterocyclic ring;R3is hydrogen or lower alkyl;R4is lower alkyl;hetaryl is 3H-imidazole-2,4-diyl or 1H-pyrazole-1,4-diyl;n is 1 or 2; andm is 1 or 2;and to pharmaceutically acceptable acid addition salts thereof. These compounds may be used for the treatment of Alzheimer's disease, Parkinson's disease, Huntington's disease, neuroprotection, schizophrenia, anxiety, pain, respiration deficits, depression, ADHD, drug addiction, such as amphetamine, cocaine, opioids, ethanol, nicotine, cannabinoids, or for the treatment of asthma, allergic responses, hypoxia, ischaemia, seizure and substance abuse, or for use as sedatives, muscle relaxants, antipsychotics, antiepileptics, anticonvulsants and cardiaprotective agents for coronary artery disease and heart failure.
REFERENCES:
patent: 6599901 (2003-07-01), Flohr et al.
patent: 6620811 (2003-09-01), Flohr et al.
patent: 6727247 (2004-04-01), Flohr et al.
patent: 7019001 (2006-03-01), Flohr et al.
patent: WO 01/97786 (2001-12-01), None
patent: WO 03/043634 (2003-05-01), None
patent: WO 03/043636 (2003-05-01), None
patent: WO 03/049741 (2003-06-01), None
patent: WO 03/053946 (2003-07-01), None
Poulsen, S. A. et al., Bioorganic & Medicinal Chemistry, vol. 6 (1998) pp. 619-641.
Müller, C. E. et al., Bioorganic & Medicinal Chemistry, vol. 6 (1998), pp. 707-719.
Kim, Y. C. et al., J. Med. Chem., (1998), vol. 41, pp. 2835-2845.
Li, A. et al., J. Med. Chem., (1998), vol. 41, pp. 3186-3201.
Baraldi, P.G. et al., J. Med. Chem., (1998), vol. 41, pp. 2126-2133.
Li, A. et al., J. Med. Chem., (1999), vol. 42, pp. 706-721.
Baraldi, P. G. et al., J. Med. Chem., (1996), vol. 39, pp. 1164-1171.
Colotta, V. et al., Arch. Pharm. Med. Chem., vol. 332, pp. 39-41 (1999).
Auchampach, J. A. et al., Am. J. Physiol., vol. 276, pp. H1113-H1116 (1999).
Haas, H. L. et al., Naunyn Schmied, Arch. Pharmacol. vol. 362, pp. 375-381 (2000).
Dionisotti, S. et al., Br. J. Pharmacol. vol. 121, pp. 353-360 (1997).
Flohr Alexander
Riemer Claus
Hoffmann-La Roche Inc.
Johnston George W.
Prior Kimberly J.
Rocha-Tramaloni Patricia S.
Shameem Golam M. M.
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