Tumor inhibiting tetrapeptide bearing modified phenethyl amides

Details Tumor inhibiting tetrapeptide bearing modified phenethyl amides Tumor inhibiting tetrapeptide bearing modified phenethyl amides

1992-12-03

1997-06-03

Scheiner, Toni R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530330, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

056354835

ABSTRACT:
New tetrapeptides bearing modified phenethyl amides are elucidated and syesized and found to exhibit tumor inhibiting effects when measured against the NCI screen for six major types of human cancer and against the murine P388 lymphocytic cell line. The new modified tetrapeptides phenethyl amides are 6(a-k).

REFERENCES:
patent: 4816444 (1989-03-01), Pettit et al.
J. Biol. Chem. vol. 266, No. 24 (Aug. 25, 1991) pp. 15882-15889.
Biochem. Pharm. vol. 40 No. 8 (Oct. 15, 1990) pp. 1859-1864.
The Peptides vol. 2 Gross & Meinnhofer (Acad. Press 1980) pp. 102-103.
Tetra. Lett. vol. 32 No. 21 pp. 2395-2398 (May 20, 1991).

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