Drosophila G protein coupled receptors, nucleic acids, and...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C436S501000

Reexamination Certificate

active

10736048

ABSTRACT:
The present invention provides aDrosophila melanogasterGPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.

REFERENCES:
patent: 4343940 (1982-08-01), Kreighbaum et al.
patent: 4399216 (1983-08-01), Axel et al.
patent: 4447608 (1984-05-01), Jones et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4757072 (1988-07-01), Kabbe et al.
patent: 4879236 (1989-11-01), Smith et al.
patent: 5217999 (1993-06-01), Levitzki et al.
patent: 5302606 (1994-04-01), Spada et al.
patent: 5316553 (1994-05-01), Kaul et al.
patent: 5330992 (1994-07-01), Eissenstat et al.
patent: 5585277 (1996-12-01), Bowie et al.
patent: 5753615 (1998-05-01), Thorpe et al.
patent: 5880141 (1999-03-01), Tang et al.
patent: 6703491 (2004-03-01), Homburger et al.
patent: 2003/0162223 (2003-08-01), Lowery
patent: 0 367 566 (1990-05-01), None
patent: 0 520 722 (1992-12-01), None
patent: 0 562 734 (1993-09-01), None
patent: 0 566 266 (1993-10-01), None
patent: 91/09955 (1991-07-01), None
patent: 91/15495 (1991-10-01), None
patent: 91/18982 (1991-12-01), None
patent: 92/20642 (1992-11-01), None
patent: 92/20808 (1992-11-01), None
patent: 92/21660 (1992-12-01), None
patent: 93/11236 (1993-06-01), None
patent: 94/03427 (1994-02-01), None
patent: 94/12650 (1994-06-01), None
patent: 94/14808 (1994-07-01), None
patent: 95/20652 (1995-08-01), None
patent: 96/22976 (1996-08-01), None
patent: 97/09433 (1997-03-01), None
patent: 98/37177 (1998-08-01), None
patent: WO 00/62615 (2000-10-01), None
patent: WO 01/310005 (2001-05-01), None
patent: WO 01/71042 (2001-09-01), None
Allen et al., “Modulation of CD4 by Suramin”,Clin. Exp. Immunol., 1993, vol. 91, pp. 141-156.
Altschul et al., “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs,”Nucl. Acids Res., 1997, 25(17), 3389-3402.
Altschul et al., “Basic Local Alignment Search Tool,”J. Mol. Biol., 1990, 215, 403-410.
Anafi et al., “Tyrphostin-Induced Inhibition of p210bcr-ablTyrosine Kinase Activity Induces K562 to Differentiate”,Blood, 1993, vol. 82, No. 12, pp. 3524-3529.
Anderson, W. F., “Human gene therapy,”Science, 1992, 256, 808-813.
Aukrust et al., “Enhanced Levels of Soluble and Membrane-Bound CD40 Ligand in Patients with Unstable Angina. Possible Reflection of T Lymphocyte and Platelet Involvement in the Pathogenesis of Acute Coronary Syndromes”,Circulation, 1999, vol. 100, pp. 614-620.
Ausubel, et al. (Eds.), “Chapter 6, Screening of recombinant DNA libraries,”Current Protocols in Molecular Biology, 1994, John Wiley & Sons, 6.0.1-6.4.10.
Baindur et al.,“Selective fluorescent ligands for pharmacological receptors,”Drug Dev. Res., 1994, 33, 373-398.
Baker et al., “Induction of Acetylcholine Receptor Clustering by Native Polystyrene Beads. Implication of an Endogenous Muscle-derived Signalling System”,J. Cell Sci., 1992, vol. 102, pp. 543-555.
Barker et al., “In-Vitro Activity of Non-glutamate Containing Quinazoline-based Thymidylate Synthase Inhibitors”,Proc. of Am. Assoc. for Cancer Res., 1991, vol. 32, pp. 327.
Benoist et al., “In vivo sequence requirements of the SV40 early promoter region,”Nature, 1981, 290, 304-310.
Bertino,Cancer Res., “Toward Improved Selectivity in Cancer Chemotherapy: The Richard and Hinda Rosenthal Foundation Award Lecture”, 1979, vol. 3, pp. 293-304.
Bilder et al., “Tyrphostins Inhibit PDGF-induced DNA Synthesis and Associated Early Events in Smooth Muscle Cells”,Amer. Physiol. Soc., 1991, pp. 6363-6143:C721-C730.
Birgul, N. et al., “Reverse physiology inDrosphila: Indentification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family”,The EMBO Journal, 1999, 18(21), 5892-5900.
Bohm, S. K., et al., “Regulatory mechanisms that modulate signalling by G-protein-coupled receptors,”Biochem. J., 1997, 322, 1-18.
Bossé, R. et al., “Development of nonseparation binding and functional assays for G protein-coupled receptors for high throughput screening: Pharmacological charaterization of the immobilized CCR5 receptor on FlashPlate®,”J. Biomolecular Screening, 1998, 3(4), 285-292.
Boulton, T. G., et al., “ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF,”Cell, 1991, 65, 663-675.
Brunton, V. G., et al.,Proceedings of Amer. Assoc. Cancer Res., No. 3335, 1992, 33, 558.
Bryckaert, M., et al., “Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bond marrow fibroblasts by tyrphostins,”Experimental Cell Research, 1992, 199, 255-261.
Burke, T. R., et al., “Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56ick,”J. Med. Chem., 1993, 36(4), 425-432.
Burke, T. R., et al., “Arylamides of hydroxylated isoquinolines as protein-tyrosine kinaseinhibitors,”BioOrganic Med. Chem. Ltrs., 1992, 2(12), 1771-1774.
Capecchi, M. R., “Altering the genome by homologous recombination,”Science, 1989, 244, 1288-1292.
Chambers, R. C., et al., “Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1,”Biochem J., 1998, 333, 121-127.
Choo, Y., et al., “Promoter-specific activation of gene expression directed by bacteriophage-selected zinc fingers,”J. Mol. Biol., 1997, 273, 525-532.
Cicala, C., et al., “Bronchoconstrictor effect of thrombin and thrombin receptor activating peptide in guinea-pigs in vivo,”Br. J. Pharmacol, 1999, 126, 478-484.
Cirino, G., et al., “Thrombin functions as an inflammatory mediator through activation of its receptor,”J. Exp. Med., 1996, 183, 821-827.
Colotta, F., et al., “Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin,”Am. J. Pathol, 1994, 144, 975-985.
Cosman, D., et al., “High Level Stable Expression of Human Interleukin-2 receptors in Mouse Cells Generates only Low Affinity Interleukin-2 Binding Sites,”Mol. Immunol., 1986, 23(9), 935-941.
Cosman, D., et al., “Cloning, sequence and expression of human interleukin-2 receptor,”Nature, 1984, 312, 768-771.
Curtin, N. J., et al., “Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB3717,”J. Cancer, 1986, 53, 361-368.
Dayoff, inAtlas of Protein Sequence and Structure, 1972, National Biochemical Research Foundation, Washington, D.C., 5, 124.
DiCuccio, M. N., et al., “A functional tethered ligand thrombin receptor is present on human hematopoietic progenitor cells,”Exp. Hematol, 1996, 24 914-918.
Dolle, R.E., et al., “5,7-dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase,”J. Med. Chem., 1994, 37, 2627-2629.
Dong, Z., et al., “Activation of tumoricidal properties in machrophages by lipopolysaccharide requirements protein-tyrosine kinase activity,”J. Leukocyte Biology, 1993, 53, 53-60.
Dong, Z., et al., “Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages,”J. Immunol., 1993, 151(5), 2717-2724.
Donovan, F. M., et al., “

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Drosophila G protein coupled receptors, nucleic acids, and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Drosophila G protein coupled receptors, nucleic acids, and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drosophila G protein coupled receptors, nucleic acids, and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3905344

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.