Hydride reduction of α,β-unsaturated carbonyl...

Details Hydride reduction of α,β-unsaturated carbonyl... Hydride reduction of α,β-unsaturated carbonyl...

2008-01-29

2008-01-29

Witherspoon, Sikarl A. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C568S343000, C568S458000

Reexamination Certificate

active

11285428

ABSTRACT:
Nonmetallic, chiral organic catalysts are used to catalyze the 1,4-hydride reduction of an α,β-unsaturated carbonyl compound. The α,β-unsaturated carbonyl compound may be an aldehyde or cyclic ketone, and the hydride donor may be a dihydropyridine. The reaction is enantioselective, and proceeds with a variety of hydride donors, catalysts, and substrates. The invention also provides compositions effective in carrying out the 1,4-hydride addition of α,β-unsaturated carbonyl compounds.

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