Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-01-08
2008-01-08
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S177000
Reexamination Certificate
active
10813745
ABSTRACT:
This invention provides compounds of formula I:wherein R1, R2, R3, R4, R5, R6, R7, Ar1, Ar2, E, a, b, c and z are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such compounds are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
REFERENCES:
patent: 3192210 (1965-06-01), Lunsford et al.
patent: 3192221 (1965-06-01), Lunsford et al.
patent: 3247222 (1966-04-01), Lunsford
patent: 3732247 (1973-05-01), Helsley et al.
patent: 3984557 (1976-10-01), Welstead, Jr.
patent: 4002766 (1977-01-01), Welstead, Jr.
patent: 4026897 (1977-05-01), Nakagawa et al.
patent: 4250188 (1981-02-01), Gandolfi et al.
patent: 4299813 (1981-11-01), Snyder
patent: 4460581 (1984-07-01), Schromm et al.
patent: 4594343 (1986-06-01), Shanklin, Jr.
patent: 4810713 (1989-03-01), Yanni et al.
patent: 4894219 (1990-01-01), Baker et al.
patent: 4950674 (1990-08-01), Yanni et al.
patent: 4992474 (1991-02-01), Skidmore et al.
patent: 5070087 (1991-12-01), Teng et al.
patent: 5096890 (1992-03-01), Cross et al.
patent: 5233053 (1993-08-01), Cross et al.
patent: 5340831 (1994-08-01), Cross et al.
patent: 5607950 (1997-03-01), Alker et al.
patent: 5837724 (1998-11-01), Allen et al.
patent: 5932594 (1999-08-01), Cross et al.
patent: 6268533 (2001-07-01), Gao et al.
patent: 6362371 (2002-03-01), Moran et al.
patent: 6433027 (2002-08-01), Bozung et al.
patent: 6541669 (2003-04-01), Moran et al.
patent: 6576793 (2003-06-01), Moran et al.
patent: 6593497 (2003-07-01), Choi et al.
patent: 6653323 (2003-11-01), Moran et al.
patent: 6670376 (2003-12-01), Moran et al.
patent: 6693202 (2004-02-01), Aggen et al.
patent: 6713651 (2004-03-01), Moran et al.
patent: 6747043 (2004-06-01), Moran et al.
patent: 2003/0018019 (2003-01-01), Meade et al.
patent: 25 58 501 (1976-07-01), None
patent: 0 178 946 (1986-04-01), None
patent: 0 178 947 (1986-04-01), None
patent: 0 235 463 (1987-09-01), None
patent: 0 388 054 (1990-09-01), None
patent: WO 91/09013 (1991-06-01), None
patent: WO 98/54167 (1998-12-01), None
patent: WO 99/64031 (1999-12-01), None
patent: WO 99/64035 (1999-12-01), None
patent: WO 99/64043 (1999-12-01), None
patent: WO 02/066422 (2002-08-01), None
patent: WO 2004/074276 (2004-09-01), None
Venn, Chromatographia, vol. 50, No. 7/8, pp. 407-414, Oct. 1999.
Cale et al., “A Series of Central Nervous System Stimulants Based on the 4-Substituted 3,3-Diphenyl-2-pyrrolidinone Skeleton. II”, J. Med. Chem., 10(2), pp. 214-222 (1967).
Glako Wellcome PLC, New long acting β2agonists, Expert Opin. Ther. Patents, 13(2), pp. 273-277 (2003).
Graul et al., “Darifenacin”, Drugs of the Future, 21(11), pp. 1105-1108 (1996).
Milecki et al., “Carbostyril Derivatives Having Potent β-Adrenergic Agonist Properties”, J.Med. Chem., 30, pp. 1563-1566 (1987).
Zlotos et al., “Muscarinic receptor agonists and antagonists”, Exp. Opin. Ther. Patents, 9(8), pp. 1029-1053 (1999).
Hughes Adam
Mammen Mathai
Hagenah Jeffrey A.
Seaman D. Margaret
Theravance Inc.
Tong Connie C.
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