Method for preventing or treating depression employing an ace in

Details Method for preventing or treating depression employing an ace in Method for preventing or treating depression employing an ace in

1989-12-11

1990-12-11

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514217, 514255, 514359, 514450, 514632, 514647, 5142258, A61K 3141, A61K 3154, A61K 3155, A61K 31135

Patent

active

049771450

ABSTRACT:
A method is provided for inhibiting onset of or treating depression by administering an ACE inhibitor, which is (S)-1-[6-amino-2-[[hydroxy-(4-phenylbutyl)phosphenyl]oxy]-1-oxohexyl]-L-pr oline, fosinopril or zofenopril, alone or in combination with an antidepressant drug such as lithium, over a prolonged period of treatment.

REFERENCES:
Giardina, W. J. et al., "Positive Effects of Captopril in the Behavioral Despair Swim Test," Biol Psychiatry 1989; 25:695-702.
Bosio, A. et al., "Antidepressant Activity of ACE-Inhibitors," TIPS, vol. 8, pp. 329-330, 1987 (Abstracts of 141st Annual Meeting of the American Psychiatric Assoc., Montreal, Canada, May 7-12, 1988).
Deicken, R. F., "Captopril Treatment of Depression," Biol Psychiatry, 1986; 21:1425-1428.
Zubenko, G. S., "Mood-Elevating Effect of Captopril in Depressed Patients," Am. J. Psychiatry 141:110-11, 1984.
Germain, L. et al., "Treatment of Recurrent Unipolar Major Depression with Captopril," Biol Psychiatry, 1988; 23:637-641.

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