Increasing ionization efficiency in mass spectrometry

Details Increasing ionization efficiency in mass spectrometry Increasing ionization efficiency in mass spectrometry

2007-10-02

2007-10-02

Ketter, James (Department: 1636)

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

C436S094000, C436S173000, C436S174000

Reexamination Certificate

active

10785621

ABSTRACT:
A system for the analysis of polyionic molecules by mass spectrometry is provided. The polyionic molecule is attached to a charged tag which neutralizes some of the charge on the polyionic analyte. The formed adduct with a reduced net charge is then analyzed by mass spectrometry, and the determined molecular weight of the adduct can be used to calculate the molecular weight of the analyte. Mass spectrometric analyses of polynucleotides and proteins are particularly amenable to this method.

REFERENCES:
patent: 6716634 (2004-04-01), Myerson

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