Piperidine derivatives and their use as antagonists of...

Details Piperidine derivatives and their use as antagonists of... Piperidine derivatives and their use as antagonists of...

2007-10-02

2007-10-02

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S360000

Reexamination Certificate

active

10502261

ABSTRACT:
The present invention relates to piperidine derivatives of formula (I):whereinR represents halogen or C1-4alkyl;R1represents hydrogen or C1-4alkyl;R2represents hydrogen, C1-4alkyl;R3represents hydrogen, C1-4alkyl;R4represents trifluoromethyl, C1-4alkyl, C1-4alkoxy, trifluoromethoxy or halogen;R5represents hydrogen, C1-4alkyl, C3-7cycloalkyl, C(O)R6or S(O)2R6;R6represents C1-4alkyl or C3-7cycloalkyl;m is zero or an integer from 1 to 3;n is an integer from 1 to 3;p is an integer from 1 to 2;X and Y are independently C(O) or CH2;provided thati) X and Y are not both C(O) andii) when X and Y are both CH2and p is 1, R5is not hydrogen, C1-4alkyl or C(O)R6;and pharmaceutically acceptable salts and solvates thereof, the process for their preparation and their use in the treatment of conditions mediated by tachykinins.

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