Measurement of gluconeogenesis and intermediary metabolism...

Chemistry: analytical and immunological testing – Tracers or tags

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C436S057000, C436S173000, C435S014000, C435S072000, C435S105000

Reexamination Certificate

active

09846727

ABSTRACT:
The present invention provides a combination of carbon-13 and deuterium metabolic tracers and methods that when used in conjunction with nuclear magnetic resonance spectroscopy, provide a measurement of metabolic fluxes in the target organisms. The tracers of the present invention may be taken orally during the same clinical exam. The metabolic information can be derived from blood, urine or other fluids to provide a comprehensive profile of glucogenic metabolism. The subject matter of the present invention may be applied to the study of metabolic dysfunction related to obesity, diabetes, HIV infection and a variety of other disease conditions.

REFERENCES:
patent: 5254730 (1993-10-01), Kilgore
patent: 5302520 (1994-04-01), Goux
patent: 5413917 (1995-05-01), Malloy et al.
patent: 5439803 (1995-08-01), Ross et al.
patent: 5597548 (1997-01-01), Sherry et al.
patent: 5817474 (1998-10-01), Brown
patent: 5910403 (1999-06-01), Hellerstein
patent: 5951473 (1999-09-01), Sherry et al.
patent: 6329208 (2001-12-01), Jones et al.
patent: 6642059 (2003-11-01), Chait et al.
patent: 6764817 (2004-07-01), Schneider
Magnusson et al. “Noninvasive Tracing of Krebs Cycle Metabolism in Liver,” Journal of Biological Chemistry, vol. 266, No. 11, pp. 6975-6984 (1991).
Jones et al. “An integrated 2H and 13C NMR study of gluconeogenesis and TCA cycle flux in humans,” Am. J. Physiol. Endocrinol. Metab. 281: E848-E856, (2001).
Magnusson et al. “Increased Rate of Gluconeogenesis in Type II Diabetes Mellitus,” J. Clin. Invest. vol. 90, pp. 1323-1327, (1992).□□
Consoli et al. “Determination of Krebs Cycle Metabolic Carbon Exchange In Vivo and Its Use to Estimate the Individual Contributions of Gluconeogenesis and Glycogenesis to Overall Glucose Output in Man,” J. Clin. Invest., vol. 80, pp. 1301-1310, (1987).
Schumann et al. “Metabolism of 2-14C Acetate and Its Use in Assessing Hepatic Krebs Cycle Activity and Gluconeogenesis,” J. Biol. Chem., vol. 266, No. 11, pp. 6985-6990, (1991).
Landau et al. “Use of 2H20 for Estimating Rates of Gluconeogenesis,” J. Clin. Invest., vol. 95, pp. 172-178, (1995).
Sunehag et al. “Gluconeogenesis in Very Low Birth WEight Infants Receiving Total Parenteral Nutrition,” Diabetes, vol. 48, pp. 791-800, (1999).
J.G. Jones, et al; 13C NMR Measurements of Human Gluconeogenic Fluxes After Ingestion of (U-13C) Propionate, Phenylacetate, and Acetaminiophen;American Journal of Physiology; Part I of Two Parts, pp. E843-E852; Nov. 1998.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Measurement of gluconeogenesis and intermediary metabolism... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Measurement of gluconeogenesis and intermediary metabolism..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Measurement of gluconeogenesis and intermediary metabolism... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3900341

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.