Modulation of angiogenesis and wound healing

Details Modulation of angiogenesis and wound healing Modulation of angiogenesis and wound healing

2007-08-28

2007-08-28

Nickol, Gary (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

C424S198100, C514S012200, C530S351000, C530S300000

Reexamination Certificate

active

09700813

ABSTRACT:
Methods of regulating angiogenesis, ischemic injury and/or wound healing by modulating the activity of leptin, particularly as mediated by the leptin receptor, and/or the interaction between leptin and the leptin receptor. Correspondingly, these methods can also be used to treat diseases mediated by angiogenesis, including wound healing, tumors and tumor metastasis, diabetic microangiopathy, retinal neovascularization, neovascularization of adipose tissue and fat metabolism, revascularization of necrotic tissue, enhancement or vascularization in microvascular transplants, and ovarian follicle maturation. Assays for identifying agents that modulate leptin and/or leptin receptor-mediated angiogenesis and/or wound healing and their use in treating angiogenesis-mediated diseases or conditions involving wound healing are also disclosed.

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