Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-02-19
1998-08-11
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546291, 546292, C07D21364, C07D21375, C07D21370, A61K 3144
Patent
active
057927790
ABSTRACT:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions and have the following structure: ##STR1## for example: ##STR2##
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patent: 5510369 (1996-04-01), Lumma et al.
Bernstein, et al., J. Med. Chem., 37, 3313-3326 "Nonpeptidic Inhibitors of Human Leukocyte Elastase . . . . ", 1994.
Brown et al., J. Med. Chem., "Design of Orally Active, Non-Peptidic Inhibitors of Human Leukocyte Elastase", vol. 37, No. 9, pp. 1259-1261 (1994).
Edwards et al., J. Am Chem. Soc., "Design, Synthesis, and Kenetic Evaluation of a Unique Class of Elastase Inhibitors . . . ", vol. 114, No. 5, pp. 1854-1863 (1992).
Brady Stephen F.
Lumma William C.
Lyle Terry A.
Sanderson Philip E.
Tucker Thomas J.
Merck & Co. , Inc.
Parr Richard S.
Rotman Alan L.
Winokur Mel
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