Substituted fused pyrroleoximes and fused pyrazoleoximes

Details Substituted fused pyrroleoximes and fused pyrazoleoximes Substituted fused pyrroleoximes and fused pyrazoleoximes

2007-10-16

2007-10-16

Shameem, Golam M. M. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S252060, C514S338000, C514S406000, C544S140000, C544S238000, C546S275700, C548S360100

Reexamination Certificate

active

10858496

ABSTRACT:
Disclosed are compounds of the formulaand the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1and R2are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAAbrain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAAbrain receptors and are therefore useful in the diagnosis and treatment of anxiety, depression, Down Syndrome, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are also disclosed.

REFERENCES:
patent: 5936095 (1999-08-01), DeSimone et al.
patent: 6743817 (2004-06-01), Maynard et al.
Michels et al., “GABAA Receptors: Properties and Trafficking,” Crit. Rev. Biochem. Mol. Biol., 42(1), Mar. 14, 2007.

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