Pyrido-1,2,4-thiadiazine and pyrido-1,4-thiazine derivatives, th

Details Pyrido-1,2,4-thiadiazine and pyrido-1,4-thiazine derivatives, th Pyrido-1,2,4-thiadiazine and pyrido-1,4-thiazine derivatives, th

1997-01-17

1998-08-11

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 10, 544 48, 5142242, C07D51304, A61K 3154

Patent

active

057927642

ABSTRACT:
Pyrido-1,2,4-thiadiazine and pyrido-1,4-thiazine derivatives represented by the formula ##STR1## wherein A, B, D, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, pulmonary system, the gastrointestinal system and the endocrinologic system.

REFERENCES:
patent: 5459138 (1995-10-01), Pirotte et al.
Pirotte, B., et al., Biochemical Pharma., vol. 47, No. 8, pp. 1381-1386, 1994.
Pirotte, B., et al., J. Med. Chem., vol. 36, pp. 3211-3213, 1993.
Dupont, L., et al., Acta Cryst., vol. C51, pp. 1903-1905, 1995.
Vlahos, W.D., et al., Metabolism, vol. 40, No. 8, pp. 825-829, 1991.

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