Adenosine A 3 receptor agonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Details

C514S045000, C514S047000, C514S263200, C536S027300, C536S027600, C536S027610, C544S277000

Reexamination Certificate

active

10722702

ABSTRACT:
Disclosed are novel compounds that are A3adenosine receptor agonists, useful for treating various disease states, including cancer, cardiac ischemia, leukopenia, and neutropennia.

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patent: 6770634 (2004-08-01), Zablocki et al.
patent: 6855818 (2005-02-01), Zablocki et al.
patent: WO 00/78777 (2000-12-01), None
patent: WO 00/78778 (2000-12-01), None
patent: WO 00/78779 (2000-12-01), None
Klotz et al. Naunyn-Schmiedeberg's Arch Pharm (1999), 360, 103-108.
Klotz et al: “2-Substituted N-Ethylcarboxamidoadenosine Derivatives as High-Affinity Agonists at Human A3 Adenosine Receptors”, Nauny-Schmiedeberg's Archives of Pharmacology, Springer, Berlin, DE., vol. 360, No. 2, 1999, pp. 103-108 XP000984051, ISSN: 0028-1298, compound 8, tables 1,2.
Baraldi et al: “Novel N6-(Substituted-phenylcarbamoyl) Adenosine-5′-Uronamides as Potent Agonist for A2 Adenosine Receptors”, Journal of Medicinal Chemistry, American Chemical Society, Washington, US, vol. 39, No. 3, Feb. 1996, pp. 802-806, XP002913657, ISSN: 0022-2623, conclusions on p. 804, pp. 803, col. 2, paragraph 4.

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