Process for production of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Reexamination Certificate

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C562S506000

Reexamination Certificate

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10501094

ABSTRACT:
A process for the production of a 3,3-dimethyl-2-formylcyclopropanecarboxylic acid derivative of formula (2):wherein R is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted aralkyl, which process comprises reacting a 3,3-dimethyl-2-(2-methyl-1-propenyl)cyclopropanecarboxylic acid compound of formula (1):wherein R is as defined above, with a periodic acid compound in the presence of a ruthenium compound.

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patent: 4014918 (1977-03-01), Martel
patent: H49 (1986-04-01), Levenberg
patent: 2002/0010361 (2002-01-01), Hagiya et al.
patent: 0 444 708 (1991-09-01), None
patent: P0100448 (2001-11-01), None
Taylor, A Convenient Synthesis of Ethyl -cis, trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate by the Wittig Reaction, 7, p. 554-555; 1980.
Journal of Labelled Compounds and Radiopharmaceuticals 13, 561-569 (1977). Nakatsuka et al.
J. Org. Chem. 2001, 66, 4814-4818. Ruthenium-Catalyzed Oxidative Cleavage of Olefins to Aldehydes. Yang et al., Jan. 31, 2001.
Database WPI, Section Ch, Week 199340, Derwent Publications Ltd., London, GB.
Database WPI, Section Ch, Week, 198033, Derwent Publications Ltd., London, GB.
Crombie, L. et al., “Total Synthesis of the Macrocyclic Diterpene (-)-Casbene, the Putative Biogenetic precursor of Lathyrane, Tigliane, Ingenane, and Related Terpenoid Structures”, Journal of the Chemical Society, Perkin Transactions I, 1980, pp. 1711-1717.

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