N3 alkylated benzimidazole derivatives as MEK inhibitors

Details N3 alkylated benzimidazole derivatives as MEK inhibitors N3 alkylated benzimidazole derivatives as MEK inhibitors

2007-06-26

2007-06-26

Stockton, Laura L. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

C548S113000

Reexamination Certificate

active

10652733

ABSTRACT:
Disclosed are compounds of the formula Iand pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9and R10are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.

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