Nucleic acid mutation detection by analysis of saliva

Details Nucleic acid mutation detection by analysis of saliva Nucleic acid mutation detection by analysis of saliva

2007-10-09

2007-10-09

Horlick, Kenneth R. (Department: 1637)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

Reexamination Certificate

active

10754478

ABSTRACT:
Methods for detection of a cell proliferative disorder, such as cancer, are provided utilizing analysis of target mutant nucleic acids in saliva specimens. The presence of the target mutant nucleic acids is indicative of a neoplastic disorder of the lung or the head and neck.

REFERENCES:
patent: 6150100 (2000-11-01), Ruschoff et al.
patent: 0 520 794 (1992-12-01), None
patent: WO93/20235 (1993-10-01), None
patent: WO93/22456 (1993-11-01), None
Hampton et al., Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semi-automated fluorescence-based detection: Subregional mapping of chromosome 4 in cervical carcinoma, 1996, Proc. Natl. Acad. Sci. USA vol. 93, pp. 6704-6709.
Fearon, Eric R., et al., “Identification of a Chromosome 18q Gene That Is Altered in Colorectal Cancers”,Science, American Association for the Advancement of Science, vol. 247(5), pp. 49-56, (1990).
Goyette, Michelle et al., “Progression of Colorectal Cancer Is Associated with Multiple Tumor Suppressor Gene Defects but Inhibition of Tumorigenicity Is Accomplished by Correction of Any Single Defect via Chromosome Transfer”,Molecular and Cellular Biology, vol. 12(3), pp. 1387-1395, (Mar. 1992).
Kinzler, K.W. et al., “Identification of a Gene Located at Chromosome 5q21 That is Mutated in Colorectal Cancers”,Science, vol. 251(15), pp. 1366-1370 (1991).
Miyoshi, Yasuo et al., “Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients”,Proc. Natl. Acad. Sci., vol. 89, pp. 4452-4456 (1992).
Nishisho, I. et al., “Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients”,Science, vol. 253(9), pp. 665-669, (1991).
Powell, Steven M., “Molecular Diagnosis of Familial Adenomatous Polyposis”,New England Journal of Medicine, vol. 329(27), pp. 1982-1987, (1993).

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