Substituted lactams as inhibitors of Aβ protein...

Details Substituted lactams as inhibitors of Aβ protein... Substituted lactams as inhibitors of Aβ protein...

2007-10-02

2007-10-02

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S523000

Reexamination Certificate

active

11005573

ABSTRACT:
This invention relates to novel lactams of Formula (I):having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

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