Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-10-09
2007-10-09
Wax, Robert A. (Department: 1656)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S255500, C530S416000
Reexamination Certificate
active
11313303
ABSTRACT:
The present invention provides a process for manufacture of purified Nematode-extracted Anticoagulant Proteins (NAPs), wherein the NAP manufactured by the claimed process method is a NAP drug substance that can be formulated as a NAP drug product. The present invention provides NAP drug substances and NAP drug products manufactured by the process disclosed herein. In one embodiment, the present invention provides a process for manufacture of rNAPc2/proline drug substance and rNAPc2/proline drug product, and provides rNAPc2/proline drug substance manufactured by the process disclosed herein.
REFERENCES:
patent: 5612198 (1997-03-01), Brierley et al.
patent: 5866543 (1999-02-01), Vlasuk et al.
patent: 6331520 (2001-12-01), Richardson
patent: 1 184 393 (2002-02-01), None
Cino, “High-Yield Protein Production fromPichia pastorisYeast:” Am. Biotech. Lab, May 1999.
Fausnaugh et al., “Solute and Mobile Phase Contributions to Retention in Hydrophobic Interaction..” J. of Chematog. 359:131-146, 1986.
Gottschalk, “Biotech Manufacturing is Coming of Age” Bioprocess. Int'l. 1(4):54-61, 2003.
Lee et al., “Dose-Response Study of Recombinant Factor VIIa/Tissue Factor Inhibitor Recombinant . . . ” Circulation 104(1):74-78, 2001.
Stanssens et al., “Anticoagulant Repertoire of the HookwormAncylostoma caninum” Proc. Nat'l. Acad. Sci. USA 93:2149-2154, 1996.
Vlasuk et al., “Inhibition of Factor VIIa/Tissue Factor with Nematode Anticoagulant . . . ” Trends in Cardiovas. Med. 12(8):325-331, 2002.
Lidell John
Mendoza Christine B.
Moss David
Dendreon Corporation
Robins & Pasternak LLP
Wax Robert A.
LandOfFree
Process for manufacture of Nematode-extracted Anticoagulant... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for manufacture of Nematode-extracted Anticoagulant..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for manufacture of Nematode-extracted Anticoagulant... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3879075