Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-02-20
2007-02-20
Shibuya, Mark L. (Department: 1639)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C536S025300, C530S333000
Reexamination Certificate
active
09859028
ABSTRACT:
A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable reagents in solutions disposed into spatially addressable flow streams to control the parallel synthesis of molecules immobilized within the channels. The reagents may be photoactivated within a subset of channels at the site of immobilized substrate molecules or at a light-addressable site upstream from the substrate molecules. The method and apparatus of the invention find particularly utility in the synthesis of biopolymer arrays, e.g., oligonucleotides, peptides and carbohydrates, and in the combinatorial synthesis of small molecule arrays for drug discovery.
REFERENCES:
patent: 4820504 (1989-04-01), Battifora
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5424186 (1995-06-01), Fodor et al.
patent: 5639603 (1997-06-01), Dower et al.
patent: 5661028 (1997-08-01), Foote
patent: 5763263 (1998-06-01), Dehlinger
patent: 5798035 (1998-08-01), Kirk et al.
patent: 6037186 (2000-03-01), Stimpson
patent: 6083697 (2000-07-01), Beecher et al.
patent: 6426184 (2002-07-01), Gao et al.
patent: 0196174 (1986-01-01), None
patent: 373203 (1994-08-01), None
patent: 93/09668 (1993-05-01), None
patent: WO 93/09668 (1993-05-01), None
patent: WO 94/08051 (1994-04-01), None
patent: WO 95/13538 (1995-05-01), None
patent: WO 95/16209 (1995-06-01), None
patent: WO 98/20967 (1998-05-01), None
patent: 99/19711 (1999-04-01), None
Banerjee et al., Protecting Groups that can be . . . , Journal of Organic Chemistry, v. 62, 6245-6251, 1997.
Acetic acid, trichloro-, ester with 2-hydroxyacetophenone, CAS reg. No. 90724-05-3, data obtained from CAOLD in STN.
New Riverside Dictionary p. 248, 1994.
Derwent Abstract No. 1999-288012 to Milstein WO 9919711, Apr. 1994.
Beatie et. al., “Advances in genosensor research,”Clinical Chemistry, 41(5): 700-706, 1995.
Bunin and Ellman, “A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives,”J. Am. Chem. Soc., 114:10997-10998, 1992.
Bunin et, al., “The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library,”Proc. Natl. Acad Sci. USA, 91(11):4708-4712, 1994.
Calvert and Pitts, Jr.,Photochemistry, John Wiley & Sons, New York, pp. 550-555, 1966.
Chen et. al., “Analogous organic synthesis of small-compound libraries: Validation of combinatorial chemistry in small-molecule synthesis,”J. Am. Chem. Soc., 116:2661-2662, 1994.
DeWitt. et. al., “Diversomers: An approach to nonpeptide, nonoligomeric chemical diversity,”Proc. Natl. Acad. Sci. USA, 90:6909-6913, 1993.
Dooley et. al., “Acetalins: Opioid receptor antagonists determined through the use of synthesis peptide combinatorial libraries,”Proc. Natl. Acad. Sci. USA, 90(22):10811-10815, 1993.
Dooley et. al., “The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands,”Life Sci., 52(18):1509-1517, 1993.
Drmanac et. al., “DNA sequence determination by hybridization: A strategy for efficient large-scale sequencing,”Science, 260:1649-1652, 1993.
Eichler et. al., “Identification of substrate-analog trypsin inhibitors through the screening of synthetic peptide combinatorial libraries,”Biochemistry, 32(41):11035-11041, 1993.
Fodor et. al., “Light-directed, spatially addressable parallel chemical synthesis,”Science, 251:767-773, 1991.
Furka et. al., “General method for rapid synthesis of multicomponent peptide mixtures,”Int. J. Pept. Protein Res., 37:487-493, 1991.
Gao et. al., “Oligonucleotide synthesis using solution photogenerated acids,”J. Am. Chem. Soc., 120, 12098-12099, 1998.
Geysen et. al., “Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid,”Proc. Natl. Acad. Sci. USA, 81:3998-4002, 1984.
Geysen et. al., “Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein,”Proc. Natl. Acad. Sci. USA, 82:178-182, 1985.
Greene and Wuts, In:Protective Groups in Organic Synthesis, John Wiley & Sons, Inc., New York, 1991.
Himmelsbach et. al., “the ρ-nitrophenylethyl (NPE) group: A versatile new blocking group for phosphate and aglycone protection in nucleosides and nucleotides,”Tetrahedron, 40: 59-72, 1984.
Houghten et. al., “Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery,”Nature, 354:84-86, 1991.
Houghten et. al., “The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides,”BioTechniques, 13(3):412-421, 1992.
Kramer et. al., “Simultaneous synthesis of peptide libraries on single resin and continuous cellulose membrane supports: Examples for the identification of protein, metal and DNA binding peptide mixtures,”Pept. Res., 6(6):314-319, 1993.
Nestler et. al., “A general method for molecular tagging of encoded combinatorial chemistry libraries,”J. Org. Chem., 59:4723-4724, 1994.
Pillai, “Photolytic deprotection and activation of functional groups,”Organic Photochemistry, Padwa, Ed., Marcel Dekker, Inc., New York, 9: 225-323, 1987.
Pinilla et. al., “Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries,”Biotechniques, 13(6):901-905, 1992.
Pinilla et. al., “Synthetic peptide combinatorial libraries (SPCLs): Identification of the antigenic determinant of β-endorphin recognized by monoclonal anibody 3E7,”Gene, 128(1):71-76, 1993.
Southern et. al., Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: Evaluation using experimental models,Genomics, 13:1008-1017, 1992.
Turro. In:Modern Molecular Photochemistry, The Benjamin/Cummings Publishing Co., Inc., Menlo Park, California, Chapter 10, pp. 362-411, 1978.
New Riverside Dictionary p. 248 1994.
Derwent Abstract No. 1999—288012 To Milstein WO 99/19711 Apr. 1994.
Banerjee et al. Protecting Groups that can be . . . , Journal of Organic Chemistry, v. 62, 6245-6251 1997.
Acetic acid, trichloro-, ester with 2-hydroxyacetophenone, CAS reg. No. 90724-05-3, data obtained from CAOLD in STN 1967.
Beatie et al., “Advances in genosensor research,” Clinical Chemistry, 41(5): 700-706, 1995.
Bunin and Ellman, “A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives,” J. Am. Chem. Soc., 114:10997-10998, 1992.
Bunin et al., “The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library,” Proc. Natl. Acad Sci. USA, 91(11):4708-4712, 1994.
Calvert and Pitts, Jr., Photochemistry, John Wiley & Sons, New York, pp. 550-555, 1966.
Chen et al., “Analogous organic synthesis of small-compound libraries: Validation of combinatorial chemistry in small-molecule synthesis,” J. Am. Chem. Soc., 116:2661-2662, 1994.
DeWitt et al., “Diversomers: An approach to nonpeptide, nonoligomeric chemical diversity,” Proc. Natl. Acad. Sci. USA, 90:6909-6913, 1993.
Dooley et al., “Acetalins: Opioid receptor antagonists determined through the use of synthesis peptide combinatorial libraries,” Proc. Natl. Acad. Sci. USA, 90(22):10811-10815, 1993.
Dooley et al., “The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands,” Life Sci., 52(18):1509-1517, 1993.
Drmanac et al., “DNA sequence determination by hybridization: A strategy for efficient large-scale sequencing,” Science, 260:1649-1652, 1993.
Eichler et al., Identification of substrate-analog trypsin inhibitors through the
Foote Robert S.
Luedeka Neely & Graham PC
Lundgren Jeffrey S.
Shibuya Mark L.
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