TIMP3 as VEGF inhibitor

Details TIMP3 as VEGF inhibitor TIMP3 as VEGF inhibitor

2007-02-27

2007-02-27

Weber, Jon (Department: 1652)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S324000, C530S350000

Reexamination Certificate

active

10804937

ABSTRACT:
Polypeptides or proteins comprising tissue inhibitor of mettaloproteinases-3 (TIMP3) or variants of TIMP3 can be used to substantially inhibit vascular endothelial growth factor (VEGF) binding to VEGF recptor-2 (VEGFR2/KDR/Flk-1)) without substantially inhibiting VEGF binding to VEGF receptor 1 (VEGFR1/Flt-1).

REFERENCES:
patent: WO 95/05478 (1995-02-01), None
patent: WO 95/09918 (1995-04-01), None
Qi et al., ARVO Annual Meeting Abstract Search and Program Planner, Abstract No. 2753, May 5-10, 2002.
Database NCBI Conserved Domain Search for Human TIMP3, printed on Oct. 28, 2005.

Affiliated with

Also associated with

Rating

TIMP3 as VEGF inhibitor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with TIMP3 as VEGF inhibitor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and TIMP3 as VEGF inhibitor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3873284