Imidazo[1,2-b]pyridazine analogues as anxiolytics and...

Details Imidazo[1,2-b]pyridazine analogues as anxiolytics and... Imidazo[1,2-b]pyridazine analogues as anxiolytics and...

2007-06-05

2007-06-05

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S236000

Reexamination Certificate

active

10680855

ABSTRACT:
The present invention provides a compound of formula I:whereinX1represents hydrogen, halogen, C1-6alkyl, trifluoromethyl or C1-6alkoxy;X2represents hydrogen or halogen;Y represents a chemical bond, an oxygen atom, or a —NH— linkage;Z represents an optionally substituted aryl or heteroaryl group;R1represents hydrogen, hydrocarbon, a heterocyclic group, halogen, cyano, trifluoromethyl, nitro, —ORa, —SRa, —SORa, —SO2Ra, —SO2NRaRb, —NRaRb, —NRaCORb, —NRaCO2Rb, —CORa, —CO2Ra, —CONRaRbor —CRa═NORb; andRaand Rbindependently represent hydrogen, hydrocarbon or a heterocyclic group; pharmaceutical compositions comprising this compound and methods of treating and/or preventing anxiety and convulsions using it.

REFERENCES:
Maubach, Medline Abstract for Current Drug Targets-CNS & Neurological Disorders, vol. 2, p. 233-239 (2003).

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