Diazabicyclic biaryl derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S349000, C544S322000, C544S323000, C544S238000, C514S275000

Reexamination Certificate

active

10513398

ABSTRACT:
This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

REFERENCES:
patent: 5478939 (1995-12-01), Trybulski et al.
patent: WO-00/34284 (2000-06-01), None
patent: WO-00/44755 (2000-08-01), None
patent: WO-01/90109 (2001-11-01), None
Mirza et al., Psychopharmacology 148(3) : 243-250, 2000.
Terry et al., Neuroscience 10192) : 357-368, 2000.
Court et al., J. Chem. Neuroanat. 20(3-4) : 281-298, 2000.

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