Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-08-28
2007-08-28
Chism, B. Dell (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600, C424S432000, C424S054000
Reexamination Certificate
active
10290694
ABSTRACT:
Thiol-linked polymeric prodrugs, methods of making and using the same are disclosed. The use of a sulfhydryl bond in combination with a benzyl elimination system results in the formation of prodrugs which can take advantage of plasma enzymes in vivo for regeneration of the parent molecule. A preferred prodrug in accordance with the invention is:where S-MP is 6-mercaptopurine.
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Choe Yun H.
Greenwald Richard B.
Chism B. Dell
Enzon Inc.
Lucas & Mercanti LLP
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