Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-08-14
2007-08-14
O'Hara, Eileen (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007920, C530S350000, C530S402000
Reexamination Certificate
active
10221125
ABSTRACT:
The present invention relates generally to a method for regulating cytokine signaling and agents useful for same. The method of the present invention is predicated in part on the identification of the molecular target of suppressor of cytokine signaling (SOCS) interaction in controlling cytokine signaling. The identification of the molecular target permits the development of assays to screen for a range of agonists and antagonists useful in modulating cytokine function. The present invention further provides, therefore, screening assays and more particularly high through-put screening assays for agonists and antagonists of SOCS-receptor interaction. Such agonists and antagonists are useful in the manufacture of medicaments for controlling cytokine signaling. Control of cytokine signaling is important for the treatment of a range of conditions including cancer, inflammatory conditions, immunological disorders and any other conditions involving aberrations of signal transduction.
REFERENCES:
patent: WO 99/40946 (1999-08-01), None
patent: WO 00/63357 (2000-10-01), None
Hibi et al. 1990. Cell 63:1149-1157.
Warren et al. 1999. J Leuk Bio. 66:588-592.
Kim et al. 1996. J Biol Chem. 271:20690-20698.
Wills, 1990, Biochemistry 29:8509-8517.
Ngo et al., 1994, The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495.
Starr R. et al., “A Family of Cytokine-Inducible Inhibitors of Signalling”,Nature 387:917-921 (1997).
Nicola N.A. et al., “The Suppressors of Cytokine Signaling (SOCS) Proteins: Important Feedback Inhibitors of Cytokine Action”,Experimental Hematology 28:1105-1112 (2000).
Bjorbaek C. et al., SOCS3 Mediates Feedback Inhibition of the Leptin Receptor Via Tyr985,The Journal of Biological Chemistry 275(51):40649-40657 (2000).
Sasaki A. et al., CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2,The Journal of Biological Chemistry 275(38):29338-29347 (2000).
Terstegen L. et al., “The Inhibition of Interleukin-6-Dependent STAT Activation by Mitogen-Activated Protein Kinases Depends on Tyrosine 759 in the Cytoplasmic Tail of Glycoprotein 130”,The Journal of Biological Chemistry 275(25):18810-18817 (2000).
Nicholson S.E. et al., “Suppressor of Cytokine Signaling-3 Preferentially Binds to the SHP-2-Binding Site on the Shared Cytokine Receptor Subunit GP 130”,PNAS 97(12):6493-6498 (2000).
Eyckerman S et al., “Identification of the Y985 and Y1077 Motifs as SOCS3 Recruitment Sites in the Murine Leptin Receptor”,FEBS Letter 486:33-37 (2000).
Krebs D.L. et al., “SOCS: Physiological Suppressors of Cytokine Signaling”,Journal of Cell Science 113:2813-2819 (2000).
Baca Manuel
Fabri Louis
Hilton Douglas
Nash Andrew
Nicholson Sandra Elaine
O'Hara Eileen
Scully , Scott, Murphy & Presser, P.C.
Shafer Shulamith H.
The Walter and Eliza Hall Institute of Medical Research
LandOfFree
Methods of regulating cytokine signalling does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of regulating cytokine signalling, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of regulating cytokine signalling will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3865084