Modulation of STAT5 expression

Details Modulation of STAT5 expression Modulation of STAT5 expression

2007-02-13

2007-02-13

McGarry, Sean (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S005000, C435S006120, C435S091200, C536S023100, C536S024300, C536S024310, C536S024330

Reexamination Certificate

active

10704263

ABSTRACT:
Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these compounds for modulation of STAT5 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT5 are provided.

REFERENCES:
patent: 5534409 (1996-07-01), Groner et al.
patent: 5618693 (1997-04-01), McKnight et al.
patent: 5801154 (1998-09-01), Baracchini et al.
patent: 5955276 (1999-09-01), Morgante et al.
patent: 5998148 (1999-12-01), Bennett et al.
patent: 6160092 (2000-12-01), Chen et al.
patent: 6444464 (2002-09-01), Wyatt
patent: 6518021 (2003-02-01), Thastrup et al.
patent: 2003/0105057 (2003-06-01), Fu et al.
patent: WO 92/05284 (1992-04-01), None
patent: WO 01/05832 (2001-01-01), None
patent: WO 02/46466 (2002-06-01), None
Leong et al. Differential function of STAT5 isoforms in head and neck cancer growth control. Oncogene 2002, vol. 21, 2846-2853. Nature Publishing Group.
Ahonen et al., Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells,J. Biol. Chem., 2003.
Ambrosio et al., The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter,Gene, 2002, 285:311-318.
Arnould et al., The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia,Hum. Mol. Genet., 1999, 8:1741-1749.
Azam et al., Functionally distinct isoforms of STAT5 are generated by protein processing,Immunity, 1997, 6:691-701.
Baskiewicz-Masiuk et al., The Role Of STAT5 Proteins In the Regulation Of Normal Hematopoiesis In A Cord Blood Model,Cell Mol. Biol. Lett., 2003, 8:317-331.
Bromberg, Stat proteins and oncogenesis,J. Clin. Invest., 2002, 109:1139-1142.
Carlesso et al., Tyrosyl phosporylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl,J. Exp. Med., 1996, 183:811-820.
Chai et al., Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients,J. Immunol., 1997, 159:4720-4728.
Coffer et al., The role of STATs in myeloid differentiation and leukemia,Oncogne, 2000, 19:2511-2522.
de Groot et al., STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells,Blood, 1999, 94:1108-1112.
Demoulin et al., Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9,J. Biol. Chem., 1999, 274:25855-25861.
Donato et al., Down-regulation of interleukin—3/granulocyte-macrophage colony-stimulating factor receptor beta-chain in BCR-ABL (+) human leukemic cells: association with loss of cytokine-mediated Stat-5 activation and protection from apoptosis after BCR-ABL inhibition,Blood, 2001, 97:2846-2853.
Dong et al., Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways,Blood, 2002, 99:2637-2646.
Gouilleux-Gruart et al., STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients,Blood, 1996, 87:1692-1697.
Grimley et al., Stat5a and Statb: fraternal twins of signal transduction and transcriptional activation,Cytokine Growth Factor Rev., 1999, 10:131-157.
Hou et al., Indentification and purification of human Stat proteins activated in response to interleukin-2,Immunity, 1995, 2:321-329.
Huang et al., Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells,Oncogene, 2002, 21: 8804-8816.
Kazansky et al., Regulation of mammary gland factor/Stat5a during mammary gland development,Mol. Endocrinol., 1995, 9:1598-1609.
Leong et al., Differential function of STAT5 isoforms in head and neck cancer growth control,Oncogene, 2002, 21:2846-2853.
Lin et al., STAT signaling in the pathogenesis and treatment of leukemias,Oncogene, 19:2496-2504.
Lin et al., Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells,J. Biol. Chem., 1996, 271:10738-10744.
Liu et al., Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue,Proc. Natl. Acad. Sci. U S A, 1995, 92:8831-8835.
Liu et al., Stat5a is mandatory for adult mammary gland development and lactogenesis,Genes Dev., 1997, 11:179-186.
Moriggl et al., Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype,Mol. Cell. Biol., 1996, 16:5691-5700.
Ripperger et al., Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements,J. Biol. Chem., 1995, 270:29998-30006.
Shuai et al., Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia,Oncogene, 1996, 13:247-254.
Spiekermann et al., Overexpression and Constitutive Activation of FLT3 Induces STAT5 Activation in Primary Acute Myeloid Leukemia Blast Cells,Clin. Cancer Res., 2003, 9:2140-2150.
Spiekermann et al., Constitutive activation of STAT3 and STAT5 is induced by leukemic fusion proteins with protein tyrosine kinase activity and is sufficient for transformation of hematopoietic precursor cells,Exp. Hematol., 2002, 30:262-271.
Takemoto et al., Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins,Proc. Natl. Acad. Sci. U S A, 1997, 94:13897-13902.
Teglund et al., Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses,Cell, 1998, 93:841-850.
Udy et al., Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression,Proc. Natl. Acad. Sci. U S A, 1997, 94:7239-7244.
Wakao et al., Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response,Embo J., 1994, 13:2182-2191.
Wang et al., Naturally occurring dominant negative variants of Stat5,Mol. Cell. Biol., 1996, 16:6141-6148.
Weber-Nordt et al., Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV) -related lymphoma cell lines,Blood, 1996, 88:809-816.
Xia et al., Expression of signal transducers and activators of transcription proteins in acute myeloid leukemia blasts,Cancer Res., 1998, 58:3173-3180.
Behod et al., Specific Inhibition on Stat5a/b Promtes Apoptosis of IL-2-Responsive Primary and Tumor-Derived Lymphoid Cells,J of Immunology, 2003, 171:3919-3927.

Affiliated with

Also associated with

Rating

Modulation of STAT5 expression does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modulation of STAT5 expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulation of STAT5 expression will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3861606