Ion channel assay methods

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S325000

Reexamination Certificate

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09804480

ABSTRACT:
A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.

REFERENCES:
patent: 4072578 (1978-02-01), Cady et al.
patent: 4461304 (1984-07-01), Kuperstein
patent: 4514500 (1985-04-01), Giaever et al.
patent: 4628933 (1986-12-01), Michelson
patent: 4677989 (1987-07-01), Robblee
patent: 4695547 (1987-09-01), Hilliard et al.
patent: 4699881 (1987-10-01), Matschke
patent: 4801543 (1989-01-01), Arnold et al.
patent: 4969468 (1990-11-01), Byers et al.
patent: 5024223 (1991-06-01), Chow
patent: 5128257 (1992-07-01), Baer
patent: 5178161 (1993-01-01), Kovacs
patent: 5187096 (1993-02-01), Giaever et al.
patent: 5194133 (1993-03-01), Clark et al.
patent: 5405367 (1995-04-01), Schulman et al.
patent: 5422272 (1995-06-01), Papp et al.
patent: 5432086 (1995-07-01), Fränzl et al.
patent: 5437982 (1995-08-01), Catterall et al.
patent: 5439440 (1995-08-01), Hofmann
patent: 5545130 (1996-08-01), Hofmann et al.
patent: 5563067 (1996-10-01), Sugihara et al.
patent: 5571158 (1996-11-01), Bolz et al.
patent: 5643742 (1997-07-01), Malin et al.
patent: 5810725 (1998-09-01), Sugihara et al.
patent: 5855801 (1999-01-01), Lin et al.
patent: 5935155 (1999-08-01), Humayun et al.
patent: 5957958 (1999-09-01), Schulman et al.
patent: 5965452 (1999-10-01), Kovacs
patent: 5972694 (1999-10-01), Mathus
patent: 5981268 (1999-11-01), Kovacs et al.
patent: 6008038 (1999-12-01), Kröger et al.
patent: 6009347 (1999-12-01), Hofmann
patent: 6024702 (2000-02-01), Iversen
patent: 6031711 (2000-02-01), Tennent et al.
patent: 6038478 (2000-03-01), Yuen et al.
patent: 6046002 (2000-04-01), Davis et al.
patent: 6051422 (2000-04-01), Kovacs et al.
patent: 6063260 (2000-05-01), Olesen et al.
patent: 6099960 (2000-08-01), Tennent et al.
patent: 6205016 (2001-03-01), Niu
patent: 6352853 (2002-03-01), King et al.
patent: 6376233 (2002-04-01), Wolf et al.
patent: 6686193 (2004-02-01), Maher et al.
patent: 1 067 378 (2001-01-01), None
patent: WO 9641166 (1996-12-01), None
patent: WO97/05922 (1997-02-01), None
patent: WO00/25121 (2000-05-01), None
patent: WO00/68686 (2000-11-01), None
Sinha SR et al. Simultaneous optical recording of evoked and spontaneous transients of membrane potential and intracellular calcium concentration with high spatio-temporal resolution.J Neurosci Methods. Aug. 1995;60(1-2):49-60.
Jacobs JM et al. Control of action potential-induced Ca2+ signaling in the soma of hippocampal neurons by Ca2+ release from intracellular stores. J Neurosci. Jun. 1, 1997;17(11):4129-35.
Gonzalez, J.E. et al. Cell-based assays and Instrumentation for screening ion channel targels. Drug Discovery Today, vol. 4, N 9 pp. 431-439 (Sep. 1999).
Mitchell RH, et al., Electrical stimulation of cultured myocardial cells. J. Biomed. Eng. 1992 vol. 14 Jan. 1992, pp. 52-56.
Tung et al. Biophysical Journal, 1992, 63(2): 371-386.
González, J.E., et al., “Cell-based assays and instrumentation for screening ion-channel targets”, Drug Discover Today, vol. 4, No. 9, pp. 431-439, (Sep. 1999).
González, J.E., et al., “Voltage sensing by fluorescence resonance energy transfer in single cells”, Biophysical Journal, vol. 69, No. 4, pp. 1272-1280, (Oct. 1995).
Giuliano, K.A., et al., “Fluorescent-protein biosensors: new tools for drug discovery”, Trends in Biotechnology, vol. 16, No. 3, pp. 135-140, (Mar. 1998).
Arndts, Oral Presentation Abstract, Second International Cell Analysis Products Users Meeting in Hilton Head Island, South Carolina, USA (Jun. 3-5, 1998).
Barr and Plonsey, Biophys. J. 61, 1164-1175 (1992).
Barr and Plonsey, IEEE 42, 1185-11911 (1995).
Cartee and Plonsey, Med & Biol. Eng. & Comp. 30 389-398 (1992).
Cartee and Plonsey, IEEE 39, 76-85 (1992).
Eppich et al., Nature Biotech. 18, 882-887 (2000).
Greenberg, et al. IEEE 46, 505-514 (1999).
Gross, et al. Biophys J. 50, 339-348 (1986).
Jentsch and Günther, BioEssays 19, 117-126 (1997).
Klee and Plonsey, Biophys. J. 12 1661-1675 (1972).
Klee and Plonsey, IEEE 23, 347-354 (1976).
Mitchell et al., J. Biomed. Eng. 14, 52-56 (1992).
Plonsey, Med & Biol. Eng. & Comput. 19 311-315 (1981).
Plonsey, Med. & Biol. Eng. & Comput. 33 337-340 (1995).
Plonsey and Barr, IEEE 42 329-336 (1995).
Plonsey and Barr, IEEE 9/10 130-137 (1998.).
Rattay, Neuroscience 89 335-346 (1999).
Roth, Critical Reviews in Biomed. Eng. 22 263-305 (1994).
Rowell, Biophotonics Int. 12 25-26 (2000).
Schmidt et al., Proc. Natl. Acad. Sci. USA 94 8948-8953 (1997).
Stone et al., J. Cardiovascular Electrophysiology 10 92-107 (1999).
Svirskis et al., American Phys. Soc. 0022-3077 579-586 (1997).
Tung and Borderies, Biophys. J. 63 371-386 (1992).
Tung et al., Circulation Research 69 722-730 (1991).
Zhou, et al., Circulation Research 83 1003-1014 (1998).
Jacobs et al., “Control of Action Potential-Induced Ca2=Signaling in the Soma of Hippocampal Neurons by Ca2+Release from Intracellular Stores”, (1997) Journal of Neuroscience 17(11):4129-4135.
Reiner et al., “Use of a Membrane Potential—Sensitive Probe to Assess Biological Expression of the Cystic Fibrosis Transmembrane Conductance Regulator” (1995) Human Gene Therapy 6:1275-1283.
Sinha et al., “Simultaneous Optical Recording of Evoked and Spontaneous Transients of Membrane Potential and Intracellular Calium Concentration with High Spatio-Temporal Resolution” (1995) Journal of Neuroscience Methods 60:49-60.
Denyer, J et al., “HTS Approaches to Voltage-Gated Ion Channel Drug Discovery Today”, (1998) 3(7): 323-332.
Brust-Mascher, I et al., “Calcium Waves Induced by Large Voltage Pulses in Fish Keratocytes”, Biophysical Journal, (1998) 75(4): 1669-1678.
Connolly, P. et al. An Extracellular Microelectrode for Monitoring Electrogenic Cells in Culture. Biosensors and Bioelectronics. 1990. 5:223-234.

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