Substituted phenypropionic acid derivatives as agonists to...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C562S452000, C564S182000, C564S169000

Reexamination Certificate

active

10499378

ABSTRACT:
The present invention provides the S enantiomer of a compound of formula (I); wherein R1represents 2,4-difluorophenyl or cyclohexyl as well as pharmaceutically acceptable salts, solvates, crystalline forms and prodrugs thereof, to processes for preparing such compounds, to their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.

REFERENCES:
patent: 4735959 (1988-04-01), Grell et al.
patent: 6258850 (2001-07-01), Andersson
patent: WO 92/05145 (1992-04-01), None
patent: WO 96/40201 (1996-12-01), None
patent: WO-99/11606 (1999-03-01), None
patent: WO-99/24442 (1999-05-01), None
patent: 2000061582 (2000-10-01), None
patent: WO-00/59889 (2000-10-01), None
patent: WO-00/61582 (2000-10-01), None
patent: WO 00/63196 (2000-10-01), None
patent: WO 00/64888 (2000-11-01), None
patent: WO-00/75103 (2000-12-01), None
patent: WO-02/44127 (2002-06-01), None
patent: WO-02/44130 (2002-06-01), None
patent: WO-02/064549 (2002-08-01), None
patent: WO-02/083616 (2002-10-01), None
patent: WO 03/051822 (2003-03-01), None
patent: WO 03/051821 (2003-06-01), None
patent: WO 2004/056748 (2004-07-01), None
patent: WO 2004/000789 (2004-12-01), None
Kirk-Othmer Encyclopedia of Chemical Technology Copyright © 2002 by John Wiley & Sons, Inc., pp. 95-147, Article Online Posting Date: Aug. 16, 2002.
Chemical & Engineering News, Feb. 24, 2003, pp. 32-35.
“The Organic Chemistry of Drug Design and Drug Action”, Silverman, 1992, pp. 19-23.
Journal of Cellular Biochemistry, vol. 55, Issue S1994A, pp. 1-11.
Adamczyk, Maciej, et al., “Use of Lipase for Regioselective One Pot Amidation and Hydrolysis,” HCAPLUS 130:251916 (1999).
Azzolina, Ornella, et al. “Antiphlogistics Aryloxypropionic Acids: Configurational Study,” HCAPLUS 120:133356 (1994).
Bagley, Scott, et al., “Phenoxyphenylacetic Acids and Derivatives Useful as Endothelin Antagonists,” HCAPLUS 125:328289 (1996).
Bagley, Scott, et al., “Preparation of Phenoxyphenlacetic Acid-Derivative Endothelin Antagonists,” HCAPLUS 125:58490 (1996).
Bagley, Scott, et al., “Preparation of Phenoxyphenylacetates and Analogs as Endothelin Receptor Antagonist,” HCAPLUS 129:67607 (1998).
Barrie, S. E. et al., “A Reappraisal of the Effect Upon Thymidine Kinase of Thymidine Derivatives Carrying Large Groups at the 5′-Position,” J. Med. Chem., vol. 27, No. 8, pp. 1044-1047 (1984).
Bauer, Klaus, et al., “Phenoxyalkane- and pheroxyalkene Carboxylic Acid, Their Derivatives and Their Use,” HCAPLUS 96:7068 (1982).
Beckh, Hansjoerg, et al., “Preparation of Sulfonamides Containing Tetrazolyl Groups and Their Use as Drugs,” HCAPLUS 113:59148 (1990).
Berge, John, et al., “Tertiary Phenethylamines,” HCAPLUS 104:5623 (1986).
Bohlmann, Ferdinand, et al., “Polyacetylene Compounds CIX. Synthesis of Natrally Occurring, Aromatic substituted Acetylene compounds,” HCAPLUS 65:99100 (1966).
Chandrakumar, Nizal Samuel, et al., “LTA4-Hydrolase Inhibitors, Pharmaceutical Compositions, and Methods of Use,” HCAPLUS 125:142725 (1996).
Chandrakumar, Nizal Samuel, et al., “Preparation of Heterocyclic LTA4 Hydrolase Inhibitors,” HCAPLUS 125:142545 (1996).
De Marchi, F., et al., “Synthesis and Pharmacological Evaluation of Some N-diethylaminoethylaryloxyacetamides and related Compounds,” HCAPLUS 79:78343 (1973).
Eakin Murdoch Allan, et al., “Preparation of N-(2-phenoxyethyl)-2-hydroxy-3-thienyloxypropylamines and Analogs as Thermogenic Agents,” HCAPLUS 114:163992 (1991).
Fex, Thomas, et al., “Preparation of N-aralkoxy-N-aralkylureas and Analogs as Antitumor Agents,” HCAPLUS 124:201795 (1995).
Cantello, Barrie Christian Charles, “2-Aminoethyl Ether Derivatives, and Their Pharmaceutical Compositions,” HCAPLUS 101:6799 (1984).
Greenlee, William J., et al., “Phenoxyphenylacetic Acid Derivatives Useful as Endothelin Antagonists,” HCAPLUS 122:31129 (1995).
Hankovszky, H. O., et al., “Benzazoles. VI. O-Alkylation of 2-(hydroxyphenyl)- and 2-(hydroxybenzyl) Benzazoles,” HCAPLUS 69:106619 (1968).
Harvey, Charolette, M., et al., “Preparation of Endothelin Receptor Antagonists for the Treatment of Emesis,” HCAPLUS 125:114587 (1996).
Hayashi, Tetsuyoshi, et al., “Insect Juvenile Hormone Mimetic activity of (4-substituted)phenoxyalkyl Compounds with Various Nitrogenous and Oxygenous Functions and Its Relationship to Their Electrostatic and Stereochemical Properties,” HCAPLUS 115:250297 (1991).
Hideg, Kalman, et al., “Alkylbenzazoles,” HCAPLUS 69:36127 (1968).
Iijima, Ikuo, et al., “Preparation of [(sulfonylamino)phenoxy]alkanoic acids as Antilipemics,” HCAPLUS 118:6741 (1993).
Iijima, Ikuo, et al., “Preparation of p-(sulfonylaminoalkyl)phenoxyalkanoic Acid Derivatives as Antilipidemics,” HCAPLUS 121:82733 (1994).
Iwakuma, Takeo, et al., “Phenoxyacetic Acids as Thromboxane A2 Antagonists and Their Preparation,” HCAPLUS 112:76612 (1990).
Iwamura, Hajime, et al., “Preparation of Phenolic Ethers as Insecticides,” HCAPLUS 116:128359 (1992).
Kraska, Allen R., “Compounds Derived from Formylphenoxyacetic Acid as Antiviral Agents in Animals,” HCAPLUS 96:34915 (1982).
Large, M. S., Smith, L.H., “β-Asrenergic Blocking Agents. 23. 1-[(Substituted-amindo)phenoxy]-3-[[(substituted-amido)alkyl]amino]propan-2-ols,” J. Med. Chem., vol. 26, No. 3, pp. 352-357 (1983).
Nametkin, et al., “Synthesis of Some Alkyl- and Aralkylphenoxyactic Acids and Their Derivatives,” ZH. Obshch. Khim., 21, pp. 2146-2147 (1951).
Nametkin, S. S., et al., “Synthesis of Some Alkyl- and Aralkylphenoxyacetic Acids and Their Derivatives,” HCAPLUS 46:48488 (1952).
Penning, Thomas D. et al., “Structure-Activity Relationship Studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4(LTA4) Hydrolase,” HCAPLUS 132:245841 (2000).
Reiffen, Manfred, et al., “Preparation of 2-thiazolyl- and 2-oxazolyl-2-alkoxy-1-aminoethane Derivatives as Antidiabetics and Antiobesity Agents,” HCAPLUS 108:221694 (1988).
Reiffen, Manfred, et al., “Preparation of Oxazole- and Thiazoleethanamines as Antidiabetics, Antiatherosclerotics, and Antiobesity Agents,” HCAPLUS 108:150463 (1988).
Sano, Hidekazu, et al., “Reversible Thermal Printing Material Containing Imide Compound as Decoloration Accelerator,” HCAPLUS 136:191709 (2002).
Sano, Hidekazu, et al., “Reversible Thermal Recording Material Containing Cyano Compound as Decoloration Accelerator,” HCAPLUS 136:175486 (2002).
Sasaki, Yasuhiko, et al., “Preparation of 4-(2-sulfonylaminoethyl)phenol Ethers as Thromboxane A2 Antagonists,” HCAPLUS 116:105828 (1992).
Stubenrauch, Gerd, et al., “Fungicidal 1,2,4-triazol-1-yl Compounds,” 94:15736 (1981).
Svab, A., et al., “Some 3-substituted Derivatives of 5-methylisoxazole with an Antiparasitic Effect,” HCAPLUS 100:82623 (1984).
Tamiz, Amir P., et al., “Structure-Activity Relationship of N-(Phenylalkyl) Cinnamides as Novel NR2B Subtype-Selective NMDA Receptor Antagonists,” HCAPLUS 131:252095 (1999).
Willson T. M. et al.: “The PPARs: From Orphan Receptor to Drug Discovery,” Journal of Medicinal Chemistry, American Chemical Society, vol. 43, No. 4, pp. 527-550 (2000).
Witte Ernst Christian, et al., “Phenoxyalkylcarboxylic Acid Derivatives,” HCAPLUS 92:6247 (1980).
Witte, Ernst Christian, et al., “Preparation of (sulfonylaminoalkyl)phenoxyacyl Amino Acids as Cardiovascular Agents,” HCAPLUS 115:280555 (1991).
Witte, Ernst, et al., “N-[[(aminoalkyl)phenyl]alkyl]- and N-[[(aminoalkoxy)phenyl]

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Substituted phenypropionic acid derivatives as agonists to... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted phenypropionic acid derivatives as agonists to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted phenypropionic acid derivatives as agonists to... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3855197

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.