Enzymatic measurement of imatinib mesylate

Details Enzymatic measurement of imatinib mesylate Enzymatic measurement of imatinib mesylate

2007-11-27

2007-11-27

Weber, Jon (Department: 1657)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

C435S194000, C600S368000

Reexamination Certificate

active

11272918

ABSTRACT:
The present invention provides a method for the enzymatic measurement of protein tyrosine kinase inhibitors in biological samples. The present invention also provides assay reagents and packaged kits useful for performing enzymatic measurement of imatinib mesylate and other bcr-abl protein kinase inhibitors in biological samples.

REFERENCES:
patent: 6599711 (2003-07-01), Crouch et al.
patent: 2003/0158105 (2003-08-01), Sawyers et al.
-Foulkes et al. (1985) J Biol Chem 260, 8070-807.
Parast et al. (Nov. 5, 1998) Biochem 37, 16788-16801.
Schulte et al. (1999) Anal Biochem 269, 245-254.
Parast CV et al (1998) Characterization and kinetic mechanism of catalytic domain of human vascular endothelial growth factor receptor-2 tyrosine kinase . . . Biochemistry 37: pp. 16788-16801.
Gambacorti-Passerini CB et al (2002) Differences between in vivo and in vitro sensitivity to imatinib of bcr/abl cells obtained from leukemic patients. Blood Cells, Molecules and Diseases 28: pp. 361-372.
Peralba JM et al (2003) Pharmacodynamic evaluation of CCI-779, an inhibitor of mTOR, in cancer patients. Clin Cancer Res 9: pp. 2887-2892.
Foulkes JG et al (1985) Purification and characterization of a protein-tyrosine kinase encoded by abelson murine leukemia virus. J Biol Chem 260: pp. 8070-8077.
The International Preliminary Report on Patentability by the International Bureau of WIPO, issued on May 31, 2007, in the PCT application No. PCT/US2005/041049.
Barker et al., Characterization of pp60c-src Tyrosine Kinase Activities Using a Continuous Assay: Autoactivation of the Enzyme Is an Intermolecular Autophosphorylation Process, Biochemistry, 34:14843-14851 (1995).
Kurzrock et al., Philadelphia Chromosome—Positive Leukemias: From Basic Mechanisms to Molecular Therapeutics, Annals of Internal Medicine, 138(10):819-831 (May 20, 2003).

Affiliated with

Also associated with

Rating

Enzymatic measurement of imatinib mesylate does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Enzymatic measurement of imatinib mesylate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enzymatic measurement of imatinib mesylate will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3852395