Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-06-19
2007-06-19
Saoud, Christine J. (Department: 1647)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069700, C435S325000, C435S243000, C435S320100, C536S023400, C536S023510, C530S399000
Reexamination Certificate
active
10733311
ABSTRACT:
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
REFERENCES:
patent: 5194596 (1993-03-01), Tischer et al.
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 5580856 (1996-12-01), Prestrelski et al.
patent: 5677278 (1997-10-01), Gospodarowicz et al.
patent: 5703047 (1997-12-01), Wilson
patent: 5731170 (1998-03-01), Rubin et al.
patent: 5773252 (1998-06-01), Greene et al.
patent: 5773586 (1998-06-01), Gospodarowicz et al.
patent: 5814605 (1998-09-01), Pierce et al.
patent: 5824643 (1998-10-01), Pierce et al.
patent: 5843883 (1998-12-01), Gospodarowicz et al.
patent: 5863767 (1999-01-01), Gospodarowicz et al.
patent: 6077692 (2000-06-01), Ruben et al.
patent: 6238888 (2001-05-01), Gentz et al.
patent: 6599879 (2003-07-01), Jimenez et al.
patent: 6653284 (2003-11-01), Gentz et al.
patent: 6693077 (2004-02-01), Ruben et al.
patent: 6869927 (2005-03-01), Gentz et al.
patent: 6903072 (2005-06-01), Ruben et al.
patent: 6916786 (2005-07-01), Ruben et al.
patent: 2002/0016295 (2002-02-01), Gentz et al.
patent: 2003/0077695 (2003-04-01), Ruben et al.
patent: 2003/0119108 (2003-06-01), Laird et al.
patent: 2003/0129687 (2003-07-01), Ruben et al.
patent: 2003/0186904 (2003-10-01), Ruben et al.
patent: 0 619 370 (1994-10-01), None
patent: 2 321 852 (1998-08-01), None
patent: 7-345689 (1995-12-01), None
patent: 8-103240 (1996-03-01), None
patent: 8-214378 (1996-07-01), None
patent: 10-330283 (1998-12-01), None
patent: 10-330284 (1998-12-01), None
patent: 10-330285 (1998-12-01), None
patent: WO 90/08771 (1990-08-01), None
patent: WO 92/14480 (1992-09-01), None
patent: WO 92/22304 (1992-12-01), None
patent: WO 93/21908 (1993-11-01), None
patent: WO 94/22427 (1994-10-01), None
patent: WO 94/23032 (1994-10-01), None
patent: WO 95/01434 (1995-01-01), None
patent: WO 95/03831 (1995-02-01), None
patent: WO 95/24928 (1995-09-01), None
patent: WO 95/24928 (1995-09-01), None
patent: WO 96/11949 (1996-04-01), None
patent: WO 96/11950 (1996-04-01), None
patent: WO 96/11951 (1996-04-01), None
patent: WO 96/11952 (1996-04-01), None
patent: WO 96/22369 (1996-07-01), None
patent: WO 96/25422 (1996-08-01), None
patent: WO 97/20929 (1997-12-01), None
patent: WO 98/06844 (1998-02-01), None
patent: WO 98/16243 (1998-04-01), None
patent: WO 98/16642 (1998-04-01), None
patent: WO 99/32135 (1999-07-01), None
patent: WO 99/41282 (1999-08-01), None
patent: WO 00/72872 (2000-12-01), None
patent: WO 01/02433 (2001-01-01), None
Phillips, Anthony. Journal of Pharmacy and Pharmacology 53: 1169-1174, 2001.
Wang et al. Nuc. Acids Res. 27: 4609-4618, 1999.
Kaufman et al. Blood 94: 3178-3184, 1999.
Abraham, et al., “Phenotypic Control of Gap Junctional Communication by Cultured Alveolar Epithelial Cells,”American Physiological Society, L825-L834 (1999).
Alderson, et al., “In Vitro and in Vivo Effects of Repifermin (Keratinocyte Growth Factor-2, KGF-2) on Human Carcinoma Cells,”Cancer Chemother Pharmacol50: 202-212 (2002).
Baneyx, F., et al., “In Vivo Degradation of Secreted Fusion Proteins by theEscherichia coliOuter Membrane Protease OmpT.”J. Bacteriology172(I):491-494 (1990).
Bass, S., et al., “Multicopy Suppressors of Prc MutantEscherichia coliInclude Two HtrA (DegP) Protease Homologs (HhoAB), DksA, and a Truncated RlpA,”J. Bacteriol. 178:1154-1161, American Society for Microbiology (1996).
Booth, et al., “Protection Against Mucosal Injury by Growth Factors and Cytokines,”Journal of the National Cancer Institute Monographs, No. 29 (2001).
Bowie, J.U., et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions,”Science247:1306-1310, American Association for the Advancement of Science (1990).
Chen et al., “Stabilization of recombinant human keratinocyte growth factor by osmolytes and salts”,J. Pharm. Sciences85(4):419-422 (1996).
Chen et al., “Aggregation pathway of recombinant human keratinocyte growth factor and its stabilization”,Pharmaceutical Research11(11):1581-1587 (1994).
Clarkson, et al., “Interventions for Preventing Oral Mucositis for Patients with Cancer Receiving Treatment (Review),”The Cochrane Collaboration(2005).
Cui, et al., “The Effect of Keratinocyte Growth Factor-2 on Esophagogastric Anastomotic Wound Healing in Rats,”Journal of Surgical Investigation, vol. 1, No. 4, 307-309 (1999).
Danilenko, D., “Preclinical and Early Clinical Development of Keratinocyte Growth Factor, an Epithelial-Specific Tissue Growth Factor,”Toxicologic Pathology, vol. 27, No. 1, 64-71 (1999).
Dodd, et al., “Factors Influencing Oral Mucositis in Patients Receiving Chemotherapy,”Cancer Practice, Nov./Dec., vol. 8, No. 6 (2000).
Dörr, et al., “Modification of Oral Mucositis by Keratinocyte Growth Factor: Single Radiation Exposure,”Int. J. Radiat. Biol., vol. 77, No. 3, 341-347 (2001).
Farrell, et al., “Keratinocyte Growth Factor Protects Mice from Chemotherapy and Radiation-induced Gastrointestinal Injury and Mortality,”Cancer Research58, 933-939, Mar. 1998.
Finch, P.W., et al., “Human KGF Is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth,”Science245:752-755, American Association for the Advancement of Science (1989).
Greenwood-Van Meerveld, et al., “Efficacy of Repifermin (Keratinocyte Growth Factor-2) Against Abnormalities in Gastrointestinal Mucosal Transport in a Murine Model of Colitis,”Journal of Pharmacy and Pharmacology, 55: 67-75 (2003).
Han et al.,“Keratinocyte Growth Factor-2 (FGF-10) Promotes Healing of Experimental Small Intestinal Ulceration in Rats,”Am J of Physiol Gastrointest Liver Physiol, 279(5, Pt. 1), G1011-G1022 (2000).
Han, et al., Database Caplus, DN 134:13722;American Journal of Physiology(2000) 279 (5, Pt. 1), G1011-G1022.
Hartung, H., et al., “Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart,”Mech. Dev. 64:31-39, Elsevier Science Ireland Ltd. (1997).
Hartung, H., et al., “AssignmentaofFgf12to mouse chromosome bands 16B1→B3 in situ hybridization,”Cytogenet. Cell Genet. 76:185-186, Karger A.G. (1997).
Haseltine, W., “Genomics and Drug Discovery,”J Am Acad Dermatol, 473-475, Sep. 2001.
Igarashi, . et al., “Characterization of Recombinant Human Fibroblast Growth Factor (FGF)—10 Reveals Functional Similarities with Keratinocyte Growth Factor (FGF-7)”,J. Biological Chemistry273(21):13230-13235 (1998).
Innes, D., et al., The cryptic ushA gene (ushAc) in natural isolates ofSalmonella enterica(serotype Typhimurium) has been inactivated by a single missense mutation,:Microbiology147; 1887-1896, Society for General Microbiology (Jul. 2001).
Jimenez, P., et al., “Effect of Topical Keratinocyte Growth Factor-2 on Wound Healing In A Glucocorticoid-Impaired Model,”J. Cutan. Pathol. 24:105, Munksgaard (1997).
Jimenez, P.A., et al., “Effect of Keratinocyte Growth Factor-2 on Cell ProliferationIn Vivo,” FASEB J. 11:AS23, Abstract No. 3025, Federation of American Societies for Experimental Biology (1997).
Jimenez, et al., “Keratinocyte Growth Factor-2 Accelerates Wound Healing in Incisional Wounds,”J. Surg. Res. 81:238-242, Academic Press, Inc. (1999).
Kelley, M.J., et al., “Emergence of the keratinocyte growth factor multigene family
Coleman Timothy A.
Dillon Patrick J.
Duan D. Roxanne
Gentz Reiner L.
Gruber Joachim R.
Human Genome Sciences Inc.
Saoud Christine J.
LandOfFree
Keratinocyte growth factor-2 polynucleotides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Keratinocyte growth factor-2 polynucleotides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Keratinocyte growth factor-2 polynucleotides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3849445