Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Reexamination Certificate
2007-08-28
2007-08-28
Wessendorf, T. D. (Department: 1639)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
C530S321000, C530S328000
Reexamination Certificate
active
10682659
ABSTRACT:
The invention includes a cell-growth-on-bead assay for screening a one-bead-one-compound combinatorial bead library to identify synthetic ligands for cell attachment and growth or proliferation of epithelial and non-epithelial cells. Cells are incubated with a compound bead library for 24 to 72-hours, allowing them to attach and grow on the beads. Those beads with cells growing are removed, and the ligand on the bead is identified. Also provided are ligands specific for cancer cells.
REFERENCES:
patent: 5510240 (1996-04-01), Lam
patent: 5635598 (1997-06-01), Lebl
patent: 5650489 (1997-07-01), Lam
patent: 5651943 (1997-07-01), Lam
patent: 5840485 (1998-11-01), Lebl
patent: 5858670 (1999-01-01), Lam
patent: 5888497 (1999-03-01), Jain
patent: 6242211 (2001-06-01), Peterson
patent: 6784153 (2004-08-01), Rajotte et al.
patent: 6933281 (2005-08-01), Ruoslahti et al.
patent: 2001/0005578 (2001-06-01), Prusiner
patent: 2004/0170955 (2004-09-01), Arap et al.
patent: WO9827231 (1998-06-01), None
Journal of the American Chemical Society (2002), 124(26), 7678-80, Liu et al.
Liu, Gang, Yemei Fan, James R. Carlson, Zhan-Gong Zhao, and Kit S. Lam. “Solution-Phase Synthesis of a 1,5-Dialkylamino-2, 4-dinitrobenzene Library and the Identification of Novel Antibacterial Compounds from This Library.”J. Comb. Chem2, No. 5 (Aug. 3, 2000): 467-474.
Lam, Kit S. “Application of combinatorial library methods in cancer research and drug discovery.”Anti-Cancer Drug Design12 (1997): 145-167.
Cabilly, S., ed.Methods in Molecular Biology, vol. 87:Combinatorial Peptide Library Protocols, chap. 1 and 2. Totowa, New Jersey: Humana Press, Inc.
Lebl, Michal, Viktor Krch{hacek over (n)}ák, Nikolai F. Sepetov, Bruce Seligmann, Peter Strop, Stephen Felder, and Kit S. Lam. “One-Bead-One-Structure Combinatorial Libraries.”Biopolymers(Peptide Science) 37 (1995): 177-198.
Liu, Gang, and Kit S. Lam. One-bead one-compound combinatorial library method. InCombinatorial Chemistry—A Practical Approach. Edited by Hicham Fenniri. Oxford University Press.
Lam, Kit S., Sydney E. Salmon, Evan M. Hersh, Victor J. Hruby, Wieslaw M. Kazmierski, and Richard J. Knapp. “A new type of synthetic peptide library for identifying ligand-binding activity.”Nature354 (Nov. 7, 1991): 82-84.
Lam, Kit S. and Michal Lebl. “Selectide Technology: Bead-Binding Screening.”Methods: A Companion to Methods in Enzymology6 (1994): 372-380.
Lam, Kit S., Zhan-Gong Zhao, Shelly Wade, Viktor Krch{hacek over (n)}ák, and Michal Lebl. “Identification of Small Peptides That Interact Specifically With a Small Organic Dye.”Drug Development Research33 (1994): 157-160.
Wu, Jinzi, Qingyan N. Ma, and Kit S. Lam. “Identifying Substrate Motifs of Protein Kinases by a Random Library Approach.”Biochemistry33 (1994): 14825-14833.
Smith, M. H., A. A. Nuara, J. G. Egen, D. B. Sirjani, K. S. Lam, and W. J. Grimes. “Baculoviral expressed HLA class I heavy chains used to screen a synthetic peptide library for Allele-Specific peptide binding motifs.”Molecular Immunology35 (1998): 1033-1043.
Pennington, Michael E., Kit S. Lam, and Anne E. Cress. “The use of a combinatorial library method to isolate human tumor cell adhesion peptides.”Molecular Diversity2 (1996): 19-28.
Lam, Kit S., Michal Lebl, and Viktor Krch{hacek over (n)}ák. “The ‘One-Bead-One-Compound’ Combinatorial Library Method.”Chem Rev97 (1997): 411-448.
Lam, Kit S. Synthetic peptide and nonpeptide libraries.Encyclopedia of Molecular Biology and Molecular Medicine5 (1996): 516-524.
Lam, Kit S., Thomas Sroka, Man-Ling Chen, Yu Zhao, Qiang Lou, Jinzi Wu, Zhan-Gong Zhao. Application of “one-Bead One-Compound” Combinational Library Methods in Single Transduction Research.Life Sciences62, Nos. 17/18 (1998): 1577-1583.
Lam, Kit S., Douglas Lake, Sydney E. Salmon, John Smith, Man-Ling Chen, Shelly Wade, Farid Abdul-Latif, Richard J. Knapp, Zuzana Leblova, Ronald D. Ferguson, Viktor Krchnak, Nikolai F. Sepetov, Michal Lebl. A One-Bead One-Peptide Combinatorial Library Method for B-Cell Epitope Mapping.METHODS: A Companion to Methods in Enzymology9 (1996): 482-493.
Park, Steven, Renil Manat, Brian Vikstrom, Nail Amro, and Kit S. Lam. “Identification of Peptide Ligands for α4β1 Integrin Receptor as Potential Targeting Agents for Non-Hodgkin's Lymphoma.”Peptides: The Wave of the Future. 2ndInternational Peptide Symposium in conjuction with the 17thAmerican Peptide Symposium. Jun. 9-14, 2001, San Diego, CA.
Clark, Peter. 1998. “Micropatterning cell adhesiveness”inImmobilized Biomolecules in Analysis—A Practical Approach. Edited by Tony Cass and Frances S. Ligler, Oxford University Press.
DeRoock, Ian B., Michael E. Pennington, Thomas C. Sroka, Kit S. Lam, G. Tim Bowden, Elisabeth L. Bair, and Anne E. Cress. “Synthetic Peptides Inhibit Adhesion of Human Tumor Cells to Extracellular Matrix Proteins.”Cancer Research61 (Apr. 15, 2001) 3308-3313.
Lau, Derick H., Linlang Guo, Ruiwu Liu, Aimin Song, Chunkui Shao, and Kit S. Lam. “Identifying peptide ligands for cell surface receptors using cell-growth-on-bead assay and one-bead one-compound combinatorial library.”Biotechnology Letters24 (2002) 497-500.
Ma{hacek over (r)}ík, Jan, Derick H. Lau, Aimin Song, Xiaobing Wang, Ruiwu Liu, Kit S. Lam. “Magnetization of Large Polystyrene Peptide Beads for Capturing and Expanding Cancer Cells.”Elsevier Science(Feb. 7, 2003).
Aina, Olulanu H., Thomas C. Sroka, Man-Ling Chen, and Kit S. Lam. “Therapeutic Cancer Targeting Peptides.” Published online Oct. 7, 2002 inWiley Interscience(www.interscience.wiley.com).
Liu, Ruiwu, Jan Ma{hacek over (r)}ík, and Kit S. Lam. “A Novel Peptide-Based Encoding System for ‘One-Bead One-Compound’ Peptidomimetic and Small Molecule Combinatorial Libraries.”J. Am. Chem Sci.124 (2002) 7678-7680.
Cardareli, Pina M., et al. “The collagen receptor alpha-2-beta-1, from MG-63 and HT1080 cells, interacts with a cyclic RGD peptide.”Journal of Biological Chemistry267 (1992) 32: 23159-23164.
Durcova, G., et al. “Immunomagnetic Isolation of Mouse Embryonic Stem Cells from Heterogeneous Cell Population.”Theriogenology47 (1997) 1: 242.
Krueger, W., et al. “Purging in Der Knochenmark- und Stammzell Transplantationl Purging in Bone Marrow and Stem Cell Transplantation.”Laboratoriumsmedizien, Kirchheim, De20 (1996) 4: 210-220.
Yang, Yi, et al. “LPAM-1 (integrin alpha4beta7)-ligand binding: Overlapping binding sites recognizing VCAM-1, MAdCAM-1 and CS-1 are blocked by fibrinogen, a fibronectin-like polymer and RGD-like cyclic peptides.”European Journal of Immunology28 (Mar. 1998) 3: 995-1004.
European Patent Application, pub. No. EP 0 332 912 A2 (Jolla Cancer Res Found) (published Sep. 20, 1989), “Inhibition of cell migration with synthetic peptides.”
Aina, Olulanu H., et al. “Identification of Novel Targeting Peptides for Human Ovarian Cancer Cells Using OBOC Combinatorial Libraries.” Draft publication submitted toMolecular Cancer Therapeutics, in about Mar. 2005.
Song, Aimin, Jinhua Zhang, Carlito B. Lebrilla, and Kit S. Lam. “A Novel and Rapid Encoding Method Based on Mass Spectrometry for ‘One-Bead-One-Compound’ Small Molecule Combinatorial Libraries.”J. Am. Chem. Soc.125 (2003): 6180-6188.
Derick Lau, Linlang Guo, Ruiwu Liu, Jan Marik, Kit Lam. “Peptide Ligands Targeting Integrin—3B1 in Non-Small Lung Cancer.” Lung Cancer (2006) 52, 291-297.
Olulanu H. Aina, Jan Marik, Regina Gandour-Edwards, Kit S. Lam. “Near-Infrared Optical Imaging of Ovarian Cancer Xenografts with Novel ∝ 3-Integrin Binding Peptide OA02.” Molecular Imaging (Oct. 2005) vol. 4, No. 4, pp. 439-447.
Olulanu H. Aina, Jan Marik, Ruiwu Liu, Derick H. Lau, and Kit S. Lam. “Identification
Lam Kit S.
Lau Derick H.
Millemann Audrey A.
The Regents of University of California
Weintraub Genshlea Chedia
Wessendorf T. D.
LandOfFree
Method for screening combinational bead library; ligands for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for screening combinational bead library; ligands for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for screening combinational bead library; ligands for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3846781