Chemistry: analytical and immunological testing – Involving immune complex formed in liquid phase
Patent
1989-03-30
1992-08-25
Lacey, David L.
Chemistry: analytical and immunological testing
Involving immune complex formed in liquid phase
436539, 436501, 436512, C01N 33536
Patent
active
051418770
ABSTRACT:
A method for the determination of the presence of free light chains (Bence Jones protein) in a unconcentrated and undiluted urine sample is provided in which the sample is reacted with an anti-free light chain antiserum reagent, where the presence of the free light chains is revealed by increase in turbidity of the reacted sample. By comparison with the turbidity of calibrators having predetermined concentrations reacted with anti-free light chain antiserum, a quantitative analysis of the amount of free light chains in the urine sample can be determined. A kit for performance of the analysis, including anti-free light chain antiserum reagent, calibrator, and reagent without antiserum, is also provided.
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Heino, J.; Rajamaki, A.; Irjalak, "Turbidimetric measurement of Bence-Jones proteins using antibodies against free light chains of immunoglobulins. An artifact caused by different polymeric forms of light chains", Scand J. Clin. Lab Invest. Apr. 1984, 44(2) pp. 173-176 see abstract Dialog A.N.=84196104.
Daley Thomas
Lacey David L.
New Scientific Company S.p.A.
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