Protein farnesyl transferase inhibitors

Details Protein farnesyl transferase inhibitors Protein farnesyl transferase inhibitors

1994-05-23

1996-06-04

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554 63, 554 78, 554 84, C07C23300

Patent

active

055234305

ABSTRACT:
Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, and inhibition of cholesterol biosynthesis, are effected by compounds of the formula ##STR1## their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs, and solvates, wherein:

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