Screening for neurotoxic amino acid associated with...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C436S090000

Reexamination Certificate

active

10731411

ABSTRACT:
Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of β-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.

REFERENCES:
patent: 6043283 (2000-03-01), Giulian
patent: 02/37122 (2002-05-01), None
Ellison, DW, Beal, MF, Mazurek, MF, Bird ED, Martin, JB. 1986. A postmortem study of amino acid transmitters in Alzheimer's disease. Ann Neurol 20:616-621.
Martinez, M, Frank, A, Diez Tejedor, E, and Hernanz, A. 1993. Amino acid concentrations in cerebrospinal fluid and serum in Alzheimer's disease and vascular dementia. J Neural Transm Park Dis Dement Sect. 6:1-9.
Cassel, CK and Ek, C. 2001. Demography and epidemiology of age-associated neuronal impairment. In PR Hof and CV Mobbs, eds., Functional Neurobiology of Aging. San Diego:Academic Press. pp. 31-50.
Spencer, PS, Nunn, PB, Hugon, J, Ludolph, A, Ross, SM, Roy, DN, Robertson, RC. 1987. Guam Amyotrophic lateral sclerosis-Parkinsonism-dementia linked to a plant neurotoxin. Science 237:517-522.
Lewin, R. 1987. Environmental hypothesis for brain diseases strengthened by new data. Science 237:483-484.
Giannakopoulos, P, Kovari, E, Gold G, Hof, PR, and Bouras, C. 2001 Types of age-related brain lesions . . . In PR Hof and CV Mobbs, eds., Functional Neurobiology of Aging. San Diego:Academic Press. pp. 65-76.
Duncan, MW, Marini, AM, Watters, R, Kopin, IJ, and Markey, SP. 1992. Zinc, a neurotoxin to cultured neurons . . . J Neurosci 12:1523-1537.
Kandel, ER, Scwhartz, JH, and Jessell, TM. 1991. Principles of Neural Science. Third Edition. New York: Elsevier.
Harvey, PD and Mohs, RC. 2001. Memory changes with aging and dementia. In PR Hof and CV Mobbs, eds., Functional Neurobiology of Aging. San Diego:Academic Press, pp. 53-63.
Alberts et al. (1994). Molecular Biology of the Cell, Third Edition. pp. 49, 56, and 132.
Banack 2002. Oral Session #89, Ecological Society of America Annual Meeting. Presented Thursday Aug. 8, 2002.
Perry 1990. Annuals of Neurology 28:12-17.
Schmidt 1998. Acta Neuropathol 95:117-122.
Deumens 2002. Experimental Neurology 175:303-317.
Bjartmar et al. 2003. J. Neurol Sci 206:165-171.
Cluskey et al. 2001. Mol Pathol 54:386-392.
Hoffner et al 2002. Biochimie 84:273-278.
Slides from presentation in Honolulu, Hawaii, Dec. 9, 2002, entitled “Island Peoples and Human Health: An Ethnobotanical Approach.”
Slides from presentation to the Plant Biotechnology and Molecular Biology Program, Colorado State University, Fort Collins, CO, Mar. 2003, entitled :“New Drugs from Old Plants.”
Slides from presentation in Stockholm, Sweden, in Jun. 2003, entitled “Biomagnification of Neurotoxins and ALS-PCD in Guam.”
Slides from presentaion to the Trustees of the Edinburgh Botanical Garden in Edinburgh, Scotland, in Jun. 2003, entitled “Botanic Gardens and Medicine.”
Hampton; Food Chain of Evidence Points to Brain Toxin; JAMA, vol. 290, No. 21; Dec. 3, 2003; p. 2788-2789.
Bannack et al., Biomagnification of cycad neurotoxins in flying foxes; Neurology, vol. 61; Aug. 2003; p. 387-389.
Armon; Western Pacific ALS/PDC and flying foxes; Neurology, vol. 61; Aug. 2003; p. 291-292.
Cox et al.; Cycad neurotoxins consumption of flying foxes, and ALS-PDC disease in Guam; Neurology, vol. 58; Mar. 2002; p. 956-959.
Manson et al; Conservation Implications of Chamorro Consumption of Flying Foxes as a Possible Cause of Amyotrophic Lateral Sclerosis-Parkinsonism Demontia Complex in Guam; Conservation Biology, vol. 17, No. 3; Jun. 2003.
Kisby et al.; Determination of β-N-methylamino-L-alanine (BMAA) in plant (Cycas circinalisL.) and animal tissue by precolumn derivatization with 9-fluorenylmethyl chloroformate (FMOC) and reversed-phase high-performance liquid chromatography; Journal of Neuroscience Methods, vol. 26, 1988; p. 45-54.
Kisby et al.; Content of the neurotoxins cycasin (methylazoxymethanol β-D-glucoside) and BMAA (β-N-methylamino-L-alanine) in cycad flour prepared by Guam Chamorros; Neurology, vol. 42; Jul. 1992; p. 1336-1340.
Duncan et al; 2-Amino-3-(methylamino)-propanoic acid (BMAA) in cycad flour; Neurology, vol. 40; May 1990; p. 767-772.
Cox et al.; Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam; PNAS, vol. 100, No. 23; Nov. 11, 2003; p. 13380-13383.
Bannack et al.; Distribution of the neurotoxic nonprotein amono acid BMAA inCycas micronesica; Botanical Journal of the Linnean Society, vol. 143; 2003; p. 165-168.
Brownson et al.; The cycad neurotoxic amino acid, β-N-methylamino-L-alanine (BMAA), elevates intracellular calcium levels in dissociated rat brain cells; Journal of Ethnopharmacology, vol. 82; 2002; p. 159-167.
Myers et al.; Neuroactive Carbamate Adducts of β-N-Methylamino-L-Alanine and Ethylenediamine; The Journal of Biological Chemistry, vol. 265, No. 18; Jun. 25, 1990; p. 10193-10195.
Forman et al.; Tau and α-Synuclein Pathology in Amygdala of Parkinsonism-Dementia Complex Patients of Guam; American Journal of Pathology, vol. 160; No. 5; May 2002; p. 1725-1731.
Oh et al., “Screening for Non-Protein Amino Acids in Seeds of the Guam Cycad,Cycas Circinalis, by an improved GC-MS Method”,Planta Med., 1995; 61: 66-70.
Kisby et al., “Determination of β-N-methylamino-L-alanine (BMAA) in plant (Cycas circinalisL.) and animal tissue by precolumn derivatization with 9-fluorenylmethyl chloroformate (FMOC) and reversed-phase high-performance liquid chromatography”,Journal of Neuroscience Methods, 1988; 26:45-54.
Wang et al., “Quantitative Analysis of Low Molecular Weight Polar Compounds by Continuous Flow Liquid Secondary Ion Tandem Mass Spectrometry”,Analytical Chemistry, May 1, 1989; 61(9):1013-1016.
Kisby et al., “Content of the neurotoxins cycasin (methylazoxymethanol β-D-glucoside) and BMAA (β-N-methylamino-L-alanine) in cycad flour prepared by Guam Chamorros”,Neurology, Jul. 1992; 42:1336-1340.
Duncan et al., “2-Amino-3-(methylamino)-propanoic acid (BMAA) in cycad flour: An unlikely cause of amyotrophic lateral sclerosis and parkinsonism-dementia of Guam”,Neurology, May 1990; 40:767-772.
Charlton et al., “Quantification of the Neurotoxin 2-Amino-3-(Methylamino)-propanoic acid (BMAA) in Cycadales”,Phytochemistry, 1992; 31(10):3429-3432.
Pan et al., “Identification of nonprotein amino acids from cycad seeds as N-ethoxycarbonyl ethyl ester derivatives by positive chemical-ionization gas chromatography-mass spectrometry”,Journal of Chromatography A, 1997; 787:288-294.
Pai et al., “Billionfold difference in the toxic potencies of two excitatatory plant amino acids, L-BOAA and L-BMAA: biochemical morphological studies using mouse brain slices”,Neuroscience Research, 1993; 17:241-248.
Duncan et al., “2-Amino-3-(Methylamino)-Propanoic Acid (BMAA) Pharmacokinetics and Blood-Brain Barrier Permeability in the Rat”,The Journal of Pharmacology and Experimental Therapeutics, 1991; 258(1):27-35.
Cox et al., “Biomagnification of cyanobacterial neurotoxins and neurogenerative disease among the Chamorro people of Guam”,PNAS, Nov. 11, 2003; 100(23):13380-13383.
Brenner et al., “Cycads: evolutionary innovations and the role of plant-derived neurotoxins”,Trends in Plant Science, Sep. 2003; 8(9):446-452.
Furey et al., “The first identifi

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Screening for neurotoxic amino acid associated with... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Screening for neurotoxic amino acid associated with..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Screening for neurotoxic amino acid associated with... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3842732

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.