Substituted imidazolidines, process for their preparation,...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S392000, C548S333100, C548S302700

Reexamination Certificate

active

10892994

ABSTRACT:
The invention relates to novel compounds of the type of the imidazolidines of the formula Iin which R1 to R7 are as defined in the claims.They are used for preparing a medicament for the treatment or prophylaxis of the central nervous system, of lipid metabolism, of infection by ectoparasites, of disorders of gall function and for improving the respiratory drive and are therefore used for treating respiratory distress.Additionally, the compounds increase the muscle tone of the upper respiratory tract, thus suppressing snoring.

REFERENCES:
patent: 3636219 (1972-01-01), Culik et al.
patent: 3638219 (1972-01-01), Culik et al.
patent: 4262005 (1981-04-01), McCarthy et al.
patent: 6005010 (1999-12-01), Schwark
patent: 6686384 (2004-02-01), Hofmeister
patent: 6825231 (2004-11-01), Heinelt
patent: WO 0121681 (2001-03-01), None
patent: WO 0172742 (2001-10-01), None
patent: WO 0179186 (2001-10-01), None
Akhter S. et al., Squalamine, A Novel Cationic Steroid, Specifically Inhibits The Brush-Border Na+/H+ Exchanger Isoform NHE3, The American Physiological Society, 278, (Cell Physiology 45), (1999) pp. C136-C144.
Ernsberger Paul et al., Clonidine Binds To Imidazole Binding Sites As Well As alpha2-Adrenoceptors in The Ventorolateral Medulla, European Journal Of Pharmacology, 134, 1, (1987) pp. 1-13.
Fliegel Larry et al., Regulation And Characterization Of The Na+/H+ Exchanger, Biochem. Cell Biology, 76, (1998), pp. 735-741.
Jen T. et al., Amidines And Related Compounds. 6. Studies On Structure-Activity Relationships Of Antihypertensive And Antisecretory Agents Related To Clonidine, Journal of Medicinal Chemistry, 18, 1, (1976), pp. 90-99.
Ma E. et al., Expression And Localization Of Na+/H+ Exchangers In Rat Central Nervous System, Neuroscience, 79, 2, (1997), pp. 591-603.
Mohsen, et al., The Cyclodesulfurization Of Thio Compounds; VII. A New Facile Synthesis Of Na-Substituted Benzimidazoles, Synthesis Communication, Jan. 1974, S. 41-42.
Omar A-Moshen M.E. et al., The Cyclodesulfurization Of Thio Compounds; XVI Dicyclohexylcarbodiimide As An Efficient Cyclodesulfurizing Agent In The Synthesis Of Heterocyclic Compounds From Various Thio Compounds, Synthesis, 1977, pp. 864-865.
Staab Heinz A. et al., Synthese Von Isothiocyanaten, Justus Liebigs Annalen Der Chemie, 657, (1962) pp. 104-107.
Turner, et al., Transepithelial Resistance can Be Regulated by the Intestinal Brush-Border Na+/H+ Exchanger NHE3, Am. J. Physiol Cell Physiol: vol. 279; 2000; pp. 1918-1924.
Yu, et al., Functional Properties of the Rat Na/H Exchanger NHE-2 Isoform Expressed in Na/H Exchanger-deficient Chinese Hamster Ovary Cells, J. Biol. Chem.; 268; 34; 1993; pp. 25536-25541.

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