Sialyltransferase and DNA encoding the same

Details Sialyltransferase and DNA encoding the same Sialyltransferase and DNA encoding the same

2007-08-14

2007-08-14

Prouty, Rebecca (Department: 1652)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S193000, C435S320100, C435S325000, C435S252300

Reexamination Certificate

active

10309389

ABSTRACT:
A sialyltransferase having the following physico-chemical properties;(1) Activity:transfers sialic acid from a sialic acid donor selectively to a 3-hydroxyl group of a galactose residue contained in lactosylceramide as a sialic acid acceptor to produce ganglioside GM3;(2) Optimal reaction pH:6.0 to 7.0; and(3) Inhibition and activation:the activity increases at least 1.5 times with 10 mm of Mn2+as compared with the case in the absence thereof.

REFERENCES:
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patent: WO 95/04816 (1995-02-01), None
patent: WO 98/42738 (1997-10-01), None
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L J Melkerson-Watson, et al. Purification to Apparent Homogeneity by Immunoaffinity Chromotography and Partial Characterization of the GM3Ganglioside-Forming Enzyme, CMP-Sialic Acid:Lactosylceramide alpha 2,3-Sialytransferase (SAT-1) from Rat Liver G. (Mar. 1991), J. Biol Chem. 266:4448-4487.
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Zeng, et al. “Regulation of Glycolipid Synthesis in HL-60 Cells by Antisense Oligodeoxynucleotides to Glycosyltransferase Sequences: Effect on Cellular Differentiation,”Proceedings of the National Academy of Sciences, vol. 92, pp. 8670-8674, Sep. 1995.
Office action and translation thereof issued on Aug. 30, 2005 to a Japanese counterpart application.
Fukumoto, et al. “Expression Cloning of Mouse cDNA of CMP-NeuAc:Lactosylceramide a2,3-Sialyltransferase, an Enzyme that Initiates the Synthesis of Gangliosides,”The Journal of Biological Chemistry, vol. 274, No. 14, pp. 9271-9276, Apr. 2, 1999.

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