Non-invasive localization of a light-emitting conjugate in a...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing

Reexamination Certificate

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C424S193100, C424S258100, C424S009610, C424S009320, C435S007350, C435S007900, C435S008000, C436S800000, C536S025320

Reexamination Certificate

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11143422

ABSTRACT:
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.

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