Process for preparing a pharmaceutically active compound

Details Process for preparing a pharmaceutically active compound Process for preparing a pharmaceutically active compound

2007-10-09

2007-10-09

Shameem, Golam M. M. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S262200

Reexamination Certificate

active

10509918

ABSTRACT:
In particular, rizatriptan or a pharmaceutically acceptable salt thereof, which includes a) Preparation of the diazonium salt of aniline hydrochloride (II); followed by reduction and acidification to give the hydrazine (III); b) reaction in situ of the hydrazine hydrochloride (III) with α-keto-δ-valerolactone, to give the hydrazone (IV); c) Fischer indole reaction of the hydrazone (IV), to give the pyranoindolone (V), optionally followed by a hydrolysis reaction to give (VI); d) Transesterification of (V) or esterification of its hydrolysis product (VI), to give (VII), where R means straight or branched C1-C4 alkyl chain; e) Conversion of the hydroxyl group of (VII) into dimethylamino, to give the indolecarboxylate (VIII), where R has the meaning defined above; f) Saponification of the 2-carboalkoxy group of (VIII) to give indolecarboxylic acid (IX); and g) Decarboxylaton of the indolecarboxylic acid (IX) to give rizatriptan and, eventually, to obtain a pharmaceutically acceptable salt thereof. The invention also relates to synthesis intermediates to obtain rizatriptan.

REFERENCES:
patent: 5567824 (1996-10-01), Chen et al.
patent: 0497512 (1992-08-01), None
patent: 2033577 (1993-03-01), None
patent: 2033578 (1993-03-01), None
patent: 9402476 (1994-02-01), None
patent: 9532197 (1995-11-01), None
patent: 9806725 (1998-02-01), None
patent: 0134561 (2001-05-01), None

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